دورية أكاديمية
A review on the role of novel adipokine Isthmin-1 and Subfatin in human type 2 diabetes mellitus
| العنوان: | A review on the role of novel adipokine Isthmin-1 and Subfatin in human type 2 diabetes mellitus |
|---|---|
| المؤلفون: | Baydaa ahmed abed, Layla Othman Farhan, Isam Noori Salman, safaa ehssan |
| المصدر: | مجلة علوم ذي قار, Vol 10, Iss 2 (2023) |
| بيانات النشر: | University of Thi-Qar, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Physics LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | Isthmin-1, diabetes mellitus, Subfatin, adipokine, insulin resistance, Physics, QC1-999, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Adipokines are essential for maintaining cardiovascular and metabolic balance. The term "adipokines" refers to peptides in the pancreas, brain, vascular system, liver, immune system and muscle. adipokines regulate numbers of factors, such as energy expenditure, hunger, satiety, insulin sensitivity, and blood pressure, insulin secretion, adipogenesis and fat distribution, and that might make them play a role in future pharmacological treatment strategies for obesity and metabolic diseases. Isthmin-1 (Ism-1) is a recently discovered insulin-like adipokine that suppresses hepatic lipids. According to recent research, Ism-1 can enhance lipid metabolism and treat metabolic disorders linked to type 2 diabetic mellitus (T2DM). The primary source of the protein subfatin (SUB) is white adipose tissue. Subfatin (SUB) is expressed in these following tissues: adipose tissue, brain tissue, thymus gland, liver, activated human monocytes, spleen, omental adipose tissue, muscle, salivary glands and heart tissues. The SUB lowers insulin resistance to control glucose metabolism. Isthmian-1 is a novel biomarker for early management and diagnosis of T2DM and has a beneficial effect in glucose homeostasis and might be therapeutic for diabetes. Subfatin also plays a role in glucose metabolism and insulin sensitivity, so it has significant effect in pathogenesis and complication of diabetes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1991-8690 2709-0256 |
| Relation: | https://jsci.utq.edu.iq/index.php/main/article/view/1129; https://doaj.org/toc/1991-8690; https://doaj.org/toc/2709-0256 |
| DOI: | 10.32792/utq/utjsci/v10i2.1129 |
| URL الوصول: | https://doaj.org/article/2cb55c1e578d4a60ac88ca01746903cf |
| رقم الأكسشن: | edsdoj.2cb55c1e578d4a60ac88ca01746903cf |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19918690 27090256 |
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| DOI: | 10.32792/utq/utjsci/v10i2.1129 |