Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling

التفاصيل البيبلوغرافية
العنوان:	Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
المؤلفون:	Willem-Jan Keune, Jens Hausmann, Ruth Bolier, Dagmar Tolenaars, Andreas Kremer, Tatjana Heidebrecht, Robbie P. Joosten, Manjula Sunkara, Andrew J. Morris, Elisa Matas-Rico, Wouter H. Moolenaar, Ronald P. Oude Elferink, Anastassis Perrakis
المصدر:	Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
بيانات النشر:	Nature Portfolio, 2016.
سنة النشر:	2016
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Autotaxin generates the bioactive lipid lysophosphatidic acid to regulate diverse biological processes. Here, the authors identify a role for bile salts as direct allosteric inhibitors of autotaxin activity, suggesting that steroids may function as regulators of lysophosphatidic acid signalling.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/ncomms11248
URL الوصول:	https://doaj.org/article/2ccdbeab88fd47eba8cb69bd11c92811
رقم الأكسشن:	edsdoj.2ccdbeab88fd47eba8cb69bd11c92811
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/ncomms11248