دورية أكاديمية

Lipoic Acid Conjugated Boron Hybrids Enhance Wound Healing and Antimicrobial Processes

التفاصيل البيبلوغرافية
العنوان: Lipoic Acid Conjugated Boron Hybrids Enhance Wound Healing and Antimicrobial Processes
المؤلفون: Hasan Türkez, Özge Çağlar Yıldırım, Sena Öner, Abdurrahim Kadı, Abdulkadir Mete, Mehmet Enes Arslan, İrfan Oğuz Şahin, Ömer Erkan Yapça, Adil Mardinoğlu
المصدر: Pharmaceutics, Vol 15, Iss 1, p 149 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Pharmacy and materia medica
مصطلحات موضوعية: wound healing, antimicrobial effect, nanoparticles, lipoic acid, boron nitride, boron carbide, Pharmacy and materia medica, RS1-441
الوصف: Complications of chronic non-healing wounds led to the emergence of nanotechnology-based therapies to enhance healing, facilitate tissue repair, and prevent wound-related complications like infections. Here, we design alpha lipoic acid (ALA) conjugated hexagonal boron nitride (hBN) and boron carbide (B4C) nanoparticles (NPs) to enhance wound healing in human dermal fibroblast (HDFa) cell culture and characterize its antimicrobial properties against Staphylococcus aureus (S. aureus, gram positive) and Escherichia coli (E. coli, gram negative) bacterial strains. ALA molecules are integrated onto hBN and C4B NPs through esterification procedure, and molecular characterizations are performed by using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and UV-vis spectroscopy. Wound healing and antimicrobial properties are investigated via the use of cell viability assays, scratch test, oxidative stress, and antimicrobial activity assays. Based on our analysis, we observe that ALA-conjugated hBN NPs have the highest wound-healing feature and antimicrobial activity compared to ALA-B4C. On the other hand, hBN, ALA-B4C, and ALA compounds showed promising regenerative and antimicrobial properties. Also, we find that ALA conjugation enhances wound healing and antimicrobial potency of hBN and B4C NPs. We conclude that the ALA-hBN conjugate is a potential candidate to stimulate regeneration process for injuries.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1999-4923
Relation: https://www.mdpi.com/1999-4923/15/1/149; https://doaj.org/toc/1999-4923
DOI: 10.3390/pharmaceutics15010149
URL الوصول: https://doaj.org/article/2cd227c1a9954e08a706fc073d3f43a3
رقم الأكسشن: edsdoj.2cd227c1a9954e08a706fc073d3f43a3
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19994923
DOI:10.3390/pharmaceutics15010149