دورية أكاديمية
أعرض في EDS

Association between plaque vulnerability and neutrophil extracellular traps (NETs) levels: The Plaque At RISK study.

التفاصيل البيبلوغرافية
العنوان: Association between plaque vulnerability and neutrophil extracellular traps (NETs) levels: The Plaque At RISK study.
المؤلفون: Judith J de Vries, Anouchska S A Autar, Dianne H K van Dam-Nolen, Samantha J Donkel, Mohamed Kassem, Anja G van der Kolk, Twan J van Velzen, M Eline Kooi, Jeroen Hendrikse, Paul J Nederkoorn, Daniel Bos, Aad van der Lugt, Moniek P M de Maat, Heleen M M van Beusekom
المصدر: PLoS ONE, Vol 17, Iss 6, p e0269805 (2022)
بيانات النشر: Public Library of Science (PLoS), 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Carotid atherosclerotic plaque rupture and its sequelae are among the leading causes of acute ischemic stroke. The risk of rupture and subsequent thrombosis is, among others, determined by vulnerable plaque characteristics and linked to activation of the immune system, in which neutrophil extracellular traps (NETs) potentially play a role. The aim of this study was to investigate how plaque vulnerability is associated with NETs levels. We included 182 patients from the Plaque At RISK (PARISK) study in whom carotid imaging was performed to measure plaque ulceration, fibrous cap integrity, intraplaque hemorrhage, lipid-rich necrotic core, calcifications and plaque volume. Principal component analysis generated a 'vulnerability index' comprising all plaque characteristics. Levels of the NETs marker myeloperoxidase-DNA complex were measured in patient plasma. The association between the vulnerability index and low or high NETs levels (dependent variable) was assessed by logistic regression. No significant association between the vulnerability index and NETs levels was detected in the total population (odds ratio 1.28, 95% confidence interval 0.90-1.83, p = 0.18). However, in the subgroup of patients naive to statins or antithrombotic medication prior to the index event, this association was statistically significant (odds ratio 2.08, 95% confidence interval 1.04-4.17, p = 0.04). Further analyses revealed that this positive association was mainly driven by intraplaque hemorrhage, lipid-rich necrotic core and ulceration. In conclusion, plaque vulnerability is positively associated with plasma levels of NETs, but only in patients naive to statins or antithrombotic medication prior to the index event.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0269805
URL الوصول: https://doaj.org/article/2ce769a19b714acdae6991e3b3c66c1b
رقم الأكسشن: edsdoj.2ce769a19b714acdae6991e3b3c66c1b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0269805