دورية أكاديمية
The Value of FET PET/CT in Recurrent Glioma with a Different IDH Mutation Status: The Relationship between Imaging and Molecular Biomarkers
| العنوان: | The Value of FET PET/CT in Recurrent Glioma with a Different IDH Mutation Status: The Relationship between Imaging and Molecular Biomarkers |
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| المؤلفون: | Marija Skoblar Vidmar, Andrej Doma, Uroš Smrdel, Katarina Zevnik, Andrej Studen |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 12, p 6787 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | glioma, treatment-related changes, true progression, pseudoprogression, radiation necrosis, biomarkers, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The evaluation of treatment response remains a challenge in glioma cases because the neuro oncological therapy can lead to the development of treatment-related changes (TRC) that mimic true progression (TP). Positron emission tomography (PET) using O-(2-[18F] fluoroethyl-)-L-tyrosine (18F-FET) has been shown to be a useful tool for detecting TRC and TP. We assessed the diagnostic performance of different 18F-FET PET segmentation approaches and different imaging biomarkers for differentiation between late TRC and TP in glioma patients. Isocitrate dehydrogenase (IDH) status was evaluated as a predictor of disease outcome. In our study, the proportion of TRC in IDH wild type (IDHwt) and IDH mutant (IDHm) subgroups was without significant difference. We found that the diagnostic value of static and dynamic biomarkers of 18F-FET PET for discrimination between TRC and TP depends on the IDH mutation status of the tumor. Dynamic 18F-FET PET acquisition proved helpful in the IDH wild type (IDHwt) subgroup, as opposed to the IDH mutant (IDHm) subgroup, providing an early indication to discontinue dynamic imaging in the IDHm subgroup. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 23126787 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/12/6787; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23126787 |
| URL الوصول: | https://doaj.org/article/2cf54a3ecc0d4a82a323abc1d60ffeaa |
| رقم الأكسشن: | edsdoj.2cf54a3ecc0d4a82a323abc1d60ffeaa |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23126787 14220067 16616596 |
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| DOI: | 10.3390/ijms23126787 |