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Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing.

التفاصيل البيبلوغرافية
العنوان: Atrial arrhythmia in ageing spontaneously hypertensive rats: unraveling the substrate in hypertension and ageing.
المؤلفون: Dennis H Lau, Nicholas J Shipp, Darren J Kelly, Shivshankar Thanigaimani, Melissa Neo, Pawel Kuklik, Han S Lim, Yuan Zhang, Karen Drury, Christopher X Wong, Nicholas H Chia, Anthony G Brooks, Hany Dimitri, David A Saint, Lindsay Brown, Prashanthan Sanders
المصدر: PLoS ONE, Vol 8, Iss 8, p e72416 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND: Both ageing and hypertension are known risk factors for atrial fibrillation (AF) although the pathophysiological contribution or interaction of the individual factors remains poorly understood. Here we aim to delineate the arrhythmogenic atrial substrate in mature spontaneously hypertensive rats (SHR). METHODS: SHR were studied at 12 and 15 months of age (n = 8 per group) together with equal numbers of age-matched normotensive Wistar-Kyoto control rats (WKY). Electrophysiologic study was performed on superfused isolated right and left atrial preparations using a custom built high-density multiple-electrode array to determine effective refractory periods (ERP), atrial conduction and atrial arrhythmia inducibility. Tissue specimens were harvested for structural analysis. RESULTS: COMPARED TO WKY CONTROLS, THE SHR DEMONSTRATED: Higher systolic blood pressure (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3754972?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0072416
URL الوصول: https://doaj.org/article/2cff63f13ab740fe9dd14e907fcdc67d
رقم الأكسشن: edsdoj.2cff63f13ab740fe9dd14e907fcdc67d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0072416