دورية أكاديمية
Progress Report: Antimicrobial Drug Discovery in the Resistance Era
| العنوان: | Progress Report: Antimicrobial Drug Discovery in the Resistance Era |
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| المؤلفون: | Pottathil Shinu, Abdulaziz K. Al Mouslem, Anroop B. Nair, Katharigatta N. Venugopala, Mahesh Attimarad, Varsha A. Singh, Sreeharsha Nagaraja, Ghallab Alotaibi, Pran Kishore Deb |
| المصدر: | Pharmaceuticals, Vol 15, Iss 4, p 413 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | antimicrobial resistance, drug discovery, drug screening, antimicrobial targets, MDR, adjuvants, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | Antibiotic resistance continues to be a most serious threat to public health. This situation demands that the scientific community increase their efforts for the discovery of alternative strategies to circumvent the problems associated with conventional small molecule therapeutics. The Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report (published in June 2021) discloses the rapidly increasing number of bacterial infections that are mainly caused by antimicrobial-resistant bacteria. These concerns have initiated various government agencies and other organizations to educate the public regarding the appropriate use of antibiotics. This review discusses a brief highlight on the timeline of antimicrobial drug discovery with a special emphasis on the historical development of antimicrobial resistance. In addition, new antimicrobial targets and approaches, recent developments in drug screening, design, and delivery were covered. This review also discusses the emergence and roles of various antibiotic adjuvants and combination therapies while shedding light on current challenges and future perspectives. Overall, the emergence of resistant microbial strains has challenged drug discovery but their efforts to develop alternative technologies such as nanomaterials seem to be promising for the future. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| Relation: | https://www.mdpi.com/1424-8247/15/4/413; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph15040413 |
| URL الوصول: | https://doaj.org/article/2d17f79e39084229a2205fa991a966ed |
| رقم الأكسشن: | edsdoj.2d17f79e39084229a2205fa991a966ed |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 |
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| DOI: | 10.3390/ph15040413 |