دورية أكاديمية
Subchronic Oral Exposure to Chlorpyrifos Decreases Butyrylcholinesterase in Wistar Ra
| العنوان: | Subchronic Oral Exposure to Chlorpyrifos Decreases Butyrylcholinesterase in Wistar Ra |
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| المؤلفون: | Elly Nurus Sakinah, Supangat Supangat, Desie Dwi Wisudanti, Cholis Abrori, Arifa Mustika, Sony Wibsono, Nabil Athoillah |
| المصدر: | Althea Medical Journal, Vol 11, Iss 1, Pp 20-25 (2024) |
| بيانات النشر: | Universitas Padjadjaran, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | butyrylcholinesterase, chlorpyrifos, toxicology, Medicine, Medicine (General), R5-920 |
| الوصف: | Background: Indonesia as an agricultural country has more than 33 million workers in the agriculture. Pesticides have an important role in agriculture because they function as powerful plant pest exterminators. However, its use is considered to cause various toxic effects, one of which is on the nervous system. This study aimed to evaluate the impact of pesticide exposure on cognitive impairment by assessing the butyrylcholinesterase biomarker in the blood of rats as experimental animals. Methods: This was a true experimental study conducted during September–November 2022 at the Pharmacology and Biochemistry Laboratory, Faculty of Medicine, University of Jember with a post-test only approach using Wistar rats which were divided into 1 control group and 4 treatment groups treated with chlorpyrifos 5 mg/kg orally. Serum butyrylcholinesterase enzyme levels were measured using the kinetic photometric method and then analyzed with a regression test in IBM SPSS® Statistics software. Results: The average value of butyrylcholinesterase was 920.23±145.27 (Control group); 904.48±91.6 (7 days after chlorpyrifos administration); 889.81±95.2 (14 days after chlorpyrifos administration); 457.84±69.5 (28 days after chlorpyrifos administration); 575.82±194.25 (56 days after chlorpyrifos administration). The results of the One-Way ANOVA test showed significant differences between groups as indicated by a significance test of 0.024 (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2337-4330 |
| Relation: | https://journal.fk.unpad.ac.id/index.php/amj/article/view/3133; https://doaj.org/toc/2337-4330 |
| DOI: | 10.15850/amj.v11n1.3133 |
| URL الوصول: | https://doaj.org/article/2d2cd1c9bfb74f0c9767e6c474afe903 |
| رقم الأكسشن: | edsdoj.2d2cd1c9bfb74f0c9767e6c474afe903 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23374330 |
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| DOI: | 10.15850/amj.v11n1.3133 |