دورية أكاديمية
Assessment of nano-iron particles impact on the reproductive health of female Wistar rats
| العنوان: | Assessment of nano-iron particles impact on the reproductive health of female Wistar rats |
|---|---|
| المؤلفون: | Menna-Tullah Magdy, Abd EL-Wahab A EL-Ghareeb, Fawzy A Attaby, Heba A Abd El-Rahman |
| المصدر: | Beni-Suef University Journal of Basic and Applied Sciences, Vol 11, Iss 1, Pp 1-16 (2022) |
| بيانات النشر: | SpringerOpen, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Science |
| مصطلحات موضوعية: | Magnetite nanoparticles, Female Wistar rat, Reproductive health, Histopathology, Hormones, Medicine (General), R5-920, Science |
| الوصف: | Abstract Background Iron oxide nanoparticles, especially nano-magnetite, are promising candidates for use in a variety of applications. The present study aimed to investigate the effect of nano-magnetite on the reproductive health of female Wistar rats. Twenty-one adult female rats were divided into three groups: Group 1 served as the control group, Group 2 received a low dose of 5 mg/kg of nano-magnetite, and Group 3 received a high dose of 10 mg/kg of nano-magnetite. For 30 days, rats were intraperitoneally injected three times per week. The main findings Revealed that nano-magnetite did not induce a change in body weight or absolute as well as relative reproductive organs weight. Nano-magnetite nanoparticles influenced the reproductive serum hormone levels as well as imbalanced the ovarian and uterine malondialdehyde and total antioxidant activity. After nano-magnetite nanoparticle injection, the histopathological examination revealed apoptosis of granulosa cells of various types of follicles, degenerated corpora lutea, congested blood vessels, and uterine epithelial cells of uterine tissue showed a high level of apoptosis and inflammation. Immunohistochemistry studies demonstrated a significant increase in activated caspase-3 following nano-magnetite injection, indicating an increase in cell apoptosis. Conclusion This study demonstrated the negative effect of magnetite nanoparticle on reproductive health and increased the likelihood of infertility. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2314-8543 |
| Relation: | https://doaj.org/toc/2314-8543 |
| DOI: | 10.1186/s43088-022-00274-4 |
| URL الوصول: | https://doaj.org/article/d2d446546c71465d9ba814a080e02cbd |
| رقم الأكسشن: | edsdoj.2d446546c71465d9ba814a080e02cbd |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 23148543 |
|---|---|
| DOI: | 10.1186/s43088-022-00274-4 |