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Therapeutic Effect of C-Vx Substance in K18-hACE2 Transgenic Mice Infected with SARS-CoV-2

التفاصيل البيبلوغرافية
العنوان: Therapeutic Effect of C-Vx Substance in K18-hACE2 Transgenic Mice Infected with SARS-CoV-2
المؤلفون: Hivda Ulbegi Polat, Irem Abaci, Arzu Tas Ekiz, Ozge Aksoy, Fatma Betul Oktelik, Vuslat Yilmaz, Saban Tekin, Alper Okyar, Oral Oncul, Gunnur Deniz
المصدر: International Journal of Molecular Sciences, Vol 24, Iss 15, p 11957 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: C-Vx, SARS-CoV-2, COVID-19, antiviral, cytokines, neutralization, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: C-Vx is a bioprotective product designed to boost the immune system. This study aimed to determine the antiviral activity of the C-Vx substance against SARS-CoV-2 infection. The effect of C-Vx in K18-hACE2 transgenic mice against the SARS-CoV-2 virus was investigated. For this purpose, ten mice were separated into experimental and control groups. Animals were infected with SARS-CoV-2 prior to the administration of the product to determine whether the product has a therapeutic effect similar to that demonstrated in previous human studies, at a histopathological and molecular level. C-Vx-treated mice survived the challenge, whereas the control mice became ill and/or died. The cytokine-chemokine panel with blood samples taken during the critical days of the disease revealed detailed immune responses. Our findings showed that C-Vx presented 90% protection against the SARS-CoV-2 virus-infected mice. The challenge results and cytokine responses of K18-hACE2 transgenic mice matched previous scientific studies, demonstrating the C-Vx’s antiviral efficiency.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/24/15/11957; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms241511957
URL الوصول: https://doaj.org/article/2d57145a7564470db3838cac8ec02046
رقم الأكسشن: edsdoj.2d57145a7564470db3838cac8ec02046
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms241511957