دورية أكاديمية
MiR-30a Inhibits the Epithelial—Mesenchymal Transition of Podocytes through Downregulation of NFATc3
| العنوان: | MiR-30a Inhibits the Epithelial—Mesenchymal Transition of Podocytes through Downregulation of NFATc3 |
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| المؤلفون: | Rui Peng, Li Zhou, Yuru Zhou, Ya Zhao, Qianyin Li, Dongsheng Ni, Yanxia Hu, Yaoshui Long, Jianing Liu, Zhongshi Lyu, Zhaomin Mao, Yue Yuan, Liyuan Huang, Hui Zhao, Ge Li, Qin Zhou |
| المصدر: | International Journal of Molecular Sciences, Vol 16, Iss 10, Pp 24032-24047 (2015) |
| بيانات النشر: | MDPI AG, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | microRNA-30a (miR-30a), podocyte, epithelial-to-mesenchymal transition (EMT), nuclear factor of activated T cells 3 (NFATc3), Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | MicroRNAs (miRNAs) possess an important regulating effect among numerous renal diseases, while their functions in the process of epithelial-to-mesenchymal transition (EMT) after podocyte injury remain unclear. The purpose of our study is to identify the potential functions of miR-30a in EMT of podocytes and explore the underlying mechanisms of miR-30a in the impaired podocytes. The results revealed that downregulation of miR-30a in podocyte injury animal models and patients, highly induced the mesenchymal markers of EMT including Collagen I, Fibronectin and Snail. Furthermore, overexpression of miR-30a enhances epithelial markers (E-cadherin) but diminished mesenchymal markers (Collagen I, Fibronectin and Snail) in podocytes. In addition, we established miR-30a target NFATc3, an important transcription factor of Non-canonical Wnt signaling pathway. More importantly, our findings demonstrated that the augmentation of miR-30a level in podocytes inhibits the nuclear translocation of NFATc3 to protect cytoskeleton disorder or rearrangement. In summary, we uncovered the protective function of miR30a targeting NFATc3 in the regulation of podocyte injury response to EMT. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | http://www.mdpi.com/1422-0067/16/10/24032; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms161024032 |
| URL الوصول: | https://doaj.org/article/da2d6f22e6734d4b8dc2325d3cd3474b |
| رقم الأكسشن: | edsdoj.2d6f22e6734d4b8dc2325d3cd3474b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms161024032 |