دورية أكاديمية
The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity.
العنوان: | The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity. |
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المؤلفون: | Annemiek B van Spriel, Mariam Sofi, Kate H Gartlan, Alie van der Schaaf, Ineke Verschueren, Ruurd Torensma, Reinier A P Raymakers, Bruce E Loveland, Mihai G Netea, Gosse J Adema, Mark D Wright, Carl G Figdor |
المصدر: | PLoS Pathogens, Vol 5, Iss 3, p e1000338 (2009) |
بيانات النشر: | Public Library of Science (PLoS), 2009. |
سنة النشر: | 2009 |
المجموعة: | LCC:Immunologic diseases. Allergy LCC:Biology (General) |
مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5 |
الوصف: | Immunoglobulin A (IgA) secretion by plasma cells in the immune system is critical for protecting the host from environmental and microbial infections. However, the molecular mechanisms underlying the generation of IgA(+) plasma cells remain poorly understood. Here, we report that the B cell-expressed tetraspanin CD37 inhibits IgA immune responses in vivo. CD37-deficient (CD37-/-) mice exhibit a 15-fold increased level of IgA in serum and significantly elevated numbers of IgA(+) plasma cells in spleen, mucosal-associated lymphoid tissue, as well as bone marrow. Analyses of bone marrow chimeric mice revealed that CD37-deficiency on B cells was directly responsible for the increased IgA production. We identified high local interleukin-6 (IL-6) production in germinal centers of CD37-/- mice after immunization. Notably, neutralizing IL-6 in vivo reversed the increased IgA response in CD37-/- mice. To demonstrate the importance of CD37-which can associate with the pattern-recognition receptor dectin-1-in immunity to infection, CD37-/- mice were exposed to Candida albicans. We report that CD37-/- mice are evidently better protected from infection than wild-type (WT) mice, which was accompanied by increased IL-6 levels and C. albicans-specific IgA antibodies. Importantly, adoptive transfer of CD37-/- serum mediated protection in WT mice and the underlying mechanism involved direct neutralization of fungal cells by IgA. Taken together, tetraspanin protein CD37 inhibits IgA responses and regulates the anti-fungal immune response. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1553-7366 1553-7374 |
Relation: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19282981/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374 |
DOI: | 10.1371/journal.ppat.1000338 |
URL الوصول: | https://doaj.org/article/2d710e37a74e4f89a83faca68b52c341 |
رقم الأكسشن: | edsdoj.2d710e37a74e4f89a83faca68b52c341 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 15537366 15537374 |
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DOI: | 10.1371/journal.ppat.1000338 |