دورية أكاديمية
Apoptotic caspases cut down the immunogenicity of radiation
| العنوان: | Apoptotic caspases cut down the immunogenicity of radiation |
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| المؤلفون: | Aitziber Buqué, Maria Esperanza Rodriguez-Ruiz, Jitka Fucikova, Lorenzo Galluzzi |
| المصدر: | OncoImmunology, Vol 8, Iss 11 (2019) |
| بيانات النشر: | Taylor & Francis Group, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | casp3, cgas, immune checkpoint blockers, mitochondrial outer membrane permeabilization, pge2, slc7a2, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon secretion. Thus, caspase inhibitors stand out as promising combinatorial partners to improve the immunogenicity of radiation therapy in the clinic. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2162-402X 2162402X |
| Relation: | https://doaj.org/toc/2162-402X |
| DOI: | 10.1080/2162402X.2019.1655364 |
| URL الوصول: | https://doaj.org/article/2d71e7a5474046659e407ad88d85df7a |
| رقم الأكسشن: | edsdoj.2d71e7a5474046659e407ad88d85df7a |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher | تدمد: | 2162402X |
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| DOI: | 10.1080/2162402X.2019.1655364 |