دورية أكاديمية
The guiding value of microvascular invasion for treating early recurrent small hepatocellular carcinoma
| العنوان: | The guiding value of microvascular invasion for treating early recurrent small hepatocellular carcinoma |
|---|---|
| المؤلفون: | Xuqi Sun, Ziliang Yang, Jie Mei, Ning Lyu, Jinfa Lai, Minshan Chen, Ming Zhao |
| المصدر: | International Journal of Hyperthermia, Vol 38, Iss 1, Pp 931-938 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medical technology |
| مصطلحات موضوعية: | hepatocellular carcinoma, recurrent, microvascular invasion, treatment, survival, Medical technology, R855-855.5 |
| الوصف: | Introduction Hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI) have worse survival. Whether the presence of MVI indicates the necessity of more aggressive locoregional treatments for recurrences remains to be elucidated. Methods We reviewed patients who underwent curative hepatectomy for primary HCC in our institution, and 379 patients with recurrent HCC up to three nodules smaller than 3 cm were enrolled. The Kaplan–Meier method was adopted to compare the secondary recurrence-free survival (sRFS) and post-recurrence survival (PRS) among patients undergoing hepatectomy, RFA and transarterial chemoembolization plus RFA (TACE-RFA). Cox regression analyses were performed to identify independent prognostic factors. Results Both the sRFS and PRS of the MVI (−) group were significantly longer than those of the MVI (+) group (p = 0.001 and 0.011). For patients with MVI (−), no significant difference was found in sRFS or PRS among recurrent HCC patients receiving hepatectomy, RFA or TACE-RFA (p = 0.149 and 0.821). A similar trend was found in patients with MVI (+) (p = 0.851 and 0.960). Further analysis found that TACE-RFA provided better sRFS than hepatectomy or RFA alone in patients with MVI (+) and early recurrence within two years (p = 0.036 and 0.044). Conclusion For HCC patients with MVI (+) and early small recurrence, TACE-RFA could achieve better prognosis than hepatectomy or RFA alone, while RFA alone provided comparable survival benefits compared with hepatectomy or TACE-RFA in other HCC patients with small recurrence. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0265-6736 1464-5157 02656736 |
| Relation: | https://doaj.org/toc/0265-6736; https://doaj.org/toc/1464-5157 |
| DOI: | 10.1080/02656736.2021.1937715 |
| URL الوصول: | https://doaj.org/article/e2d955afafe840b6ba22d64b1e77deb4 |
| رقم الأكسشن: | edsdoj.2d955afafe840b6ba22d64b1e77deb4 |
| قاعدة البيانات: | Directory of Open Access Journals |
PDF full text from Publisher 
Full Text Finder | تدمد: | 02656736 14645157 |
|---|---|
| DOI: | 10.1080/02656736.2021.1937715 |