دورية أكاديمية
Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain
| العنوان: | Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain |
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| المؤلفون: | Jake F Watson, Hinze Ho, Ingo H Greger |
| المصدر: | eLife, Vol 6 (2017) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | AMPA receptor, synapse, LTP, N-terminal domain, NTD, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | AMPA-type glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and are selectively recruited during activity-dependent plasticity to increase synaptic strength. A prerequisite for faithful signal transmission is the positioning and clustering of AMPARs at postsynaptic sites. The mechanisms underlying this positioning have largely been ascribed to the receptor cytoplasmic C-termini and to AMPAR-associated auxiliary subunits, both interacting with the postsynaptic scaffold. Here, using mouse organotypic hippocampal slices, we show that the extracellular AMPAR N-terminal domain (NTD), which projects midway into the synaptic cleft, plays a fundamental role in this process. This highly sequence-diverse domain mediates synaptic anchoring in a subunit-selective manner. Receptors lacking the NTD exhibit increased mobility in synapses, depress synaptic transmission and are unable to sustain long-term potentiation (LTP). Thus, synaptic transmission and the expression of LTP are dependent upon an AMPAR anchoring mechanism that is driven by the NTD. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/23024; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.23024 |
| URL الوصول: | https://doaj.org/article/2dad46a347e14213bc2600e64f1ef178 |
| رقم الأكسشن: | edsdoj.2dad46a347e14213bc2600e64f1ef178 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.23024 |