دورية أكاديمية
Elevated Neurofilament Light Chain in Cerebrospinal Fluid and Plasma Reflect Inflammatory MRI Activity in Neurosarcoidosis
| العنوان: | Elevated Neurofilament Light Chain in Cerebrospinal Fluid and Plasma Reflect Inflammatory MRI Activity in Neurosarcoidosis |
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| المؤلفون: | Keld-Erik Byg, Helle H. Nielsen, Tobias Sejbaek, Jonna Skov Madsen, Dorte Aalund Olsen, Nina Nguyen, Astrid Kindt, Jakob Grauslund, Zsolt Illes, Torkell Ellingsen |
| المصدر: | Brain Sciences, Vol 11, Iss 2, p 238 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | neurofilament light chain, biomarker, neurosarcoidosis, cerebrospinal fluid, MRI, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Background: Damage to axonal cells releases neurofilament light chain (NFL) into the cerebrospinal fluid and plasma. The objective of this study was to investigate NFL as a potential biomarker of disease activity in neurosarcoidosis. MRIs were graded according to enhancing lesions at different central nervous system (CNS) sites. Results: In cerebrospinal fluid, levels of NFL were higher in neurosarcoidosis patients (n = 20) median 2304 pg/mL (interquartile range (IQR) 630–19,612) compared to 426 pg/mL (IQR 261-571) in extra-neurologic sarcoidosis patients (n = 20) and 336 pg/mL (IQR 194–402) in healthy controls (n = 11) (p = 0.0002). In plasma, levels of NFL were higher in neurosarcoidosis patients median 28.2 pg/mL (IQR 11.5–49.3) compared to 6.2 pg/mL (IQR 4.3–8.2) in extra-neurologic sarcoidosis patients and 7.1 pg/mL (IQR 6.2–9.0) in healthy controls (p = 0.0001). Levels in both cerebrospinal fluid and plasma were higher in neurosarcoidosis patients with moderate/severe enhancement than patients with mild enhancement on MRI (p = 0.009 and p = 0.005, respectively). To distinguish neurosarcoidosis patients from extra-neurologic patients and healthy controls, a cut-off level of 630 pg/mL in cerebrospinal fluid had 94% specificity and 79% sensitivity, while a cut-off level of 11.4 pg/mL in plasma had 97% specificity and 75% sensitivity. Conclusions: NFL levels in cerebrospinal fluid and plasma are significantly higher in neurosarcoidosis patients compared to extra-neurologic patients and healthy controls, and the levels correlate to the extent of inflammation on MRI. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-3425 88828514 |
| Relation: | https://www.mdpi.com/2076-3425/11/2/238; https://doaj.org/toc/2076-3425 |
| DOI: | 10.3390/brainsci11020238 |
| URL الوصول: | https://doaj.org/article/d2dec8882851448088a934f41e9ec4f3 |
| رقم الأكسشن: | edsdoj.2dec8882851448088a934f41e9ec4f3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20763425 88828514 |
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| DOI: | 10.3390/brainsci11020238 |