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Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys

التفاصيل البيبلوغرافية
العنوان: Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys
المؤلفون: Hui Peng, Qianqian Wang, Tanqi Lou, Jun Qin, Sungyun Jung, Vivekananda Shetty, Feng Li, Yanlin Wang, Xin-hua Feng, William E. Mitch, Brett H. Graham, Zhaoyong Hu
المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
بيانات النشر: Nature Portfolio, 2017.
سنة النشر: 2017
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: Progressive tubule cell damage results in defects in mitochondrial metabolism and exercise seems to be beneficial during chronic kidney disease. Here Peng et al. show that irisin, an exercise-induced myokine, improves kidney energy metabolism by inhibiting TGF-β type 1 receptors and ameliorates fibrosis.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-017-01646-6
URL الوصول: https://doaj.org/article/2e02db7b780c4d058faf0b3bda3f1292
رقم الأكسشن: edsdoj.2e02db7b780c4d058faf0b3bda3f1292
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20411723
DOI:10.1038/s41467-017-01646-6