دورية أكاديمية
The effect of N-stearoylethanolamine on cholesterol content, fatty acid composition and protein carbonylation level in rats with alimentary obesity-induced insulin resistance
| العنوان: | The effect of N-stearoylethanolamine on cholesterol content, fatty acid composition and protein carbonylation level in rats with alimentary obesity-induced insulin resistance |
|---|---|
| المؤلفون: | O. V. Onopchenko, G. V. Kosiakova, E. F. Meged, V. M. Klimashevsky, N. M. Hula |
| المصدر: | The Ukrainian Biochemical Journal, Vol 86, Iss 6, Pp 119-128 (2014) |
| بيانات النشر: | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Biochemistry LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | cholesterol content, experimental insulin resistance, free fatty acid composition, liver, N-stearoylethanolamine, obesity, protein carbonylation, Biochemistry, QD415-436, Medicine, Biology (General), QH301-705.5 |
| الوصف: | The effect of N-stearoylethanolamine (NSE) on liver free fatty acid composition, cholesterol content and carbonylated protein level in rats with obesity-induced insulin resistance (IR) was studied in the work. The experimental insulin resistance was induced by prolonged high fat diet (58% of energy derived from fat) for 6 months combined with one injection of low-dose (15 mg/kg) of streptozotocin. The lipid assay showed a rise in liver free cholesterol content and a significant reduction in cholesterol esters level. Analyzing liver fatty acid composition, a decrease in polyunsaturated of fatty acid (PUFA) level and an increase in monounsaturated fatty acid (MUFA) content was found. Fatty acid imbalance with high content of MUFA was associated with elevated level of protein carbonylation. The NSE administration (50 mg/kg of body weight) for 2 weeks decreased free cholesterol content, increased cholesterol esters level and reduced free oleic fatty acid content in the liver of rats with IR. The effect of NSE on lipid imbalance led to a decrease in protein carbonylation level that may result in improvement of transmembrane protein function under obesity-induced insulin resistance state. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2409-4943 2413-5003 |
| Relation: | http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Onopchenko_6_14.pdf; https://doaj.org/toc/2409-4943; https://doaj.org/toc/2413-5003 |
| DOI: | 10.15407/ubj86.06.119 |
| URL الوصول: | https://doaj.org/article/2e2e351838914b1ebae1a533300200f5 |
| رقم الأكسشن: | edsdoj.2e2e351838914b1ebae1a533300200f5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24094943 24135003 |
|---|---|
| DOI: | 10.15407/ubj86.06.119 |