دورية أكاديمية
Systolic heart failure induced by butylparaben in zebrafish is caused through oxidative stress and immunosuppression
| العنوان: | Systolic heart failure induced by butylparaben in zebrafish is caused through oxidative stress and immunosuppression |
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| المؤلفون: | Hui Zhu, Dalong Liao, Muhammad Aamer Mehmood, Yong Huang, Wei Yuan, Jia Zheng, Yi Ma, Yuyang Peng, Guiyou Tian, Xiaoping Xiao, Chaohua Lan, Linman Li, Kewei Xu, Huiqiang Lu, Ning Wang |
| المصدر: | Ecotoxicology and Environmental Safety, Vol 268, Iss , Pp 115692- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Environmental pollution LCC:Environmental sciences |
| مصطلحات موضوعية: | Butylparaben, Zebrafish, Systolic heart failure, Oxidative stress, Immunosuppression, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| الوصف: | Due to Butylparaben (BuP) widespread application in cosmetics, food, pharmaceuticals, and its presence as an environmental residue, human and animal exposure to BuP is common, potentially posing hazards to both human and animal health. Congenital heart disease is already a serious problem. However, the effects of BuP on the developing heart and its underlying mechanisms remain unclear. Here, zebrafish embryos were exposed to environmentally and human-relevant concentrations of BuP (0.6 mg/L, 1.2 mg/L, and 1.8 mg/L, calculated but not measured) at 6 h post-fertilization (hpf) and were treated until 72 hpf. Exposure to BuP led to cardiac morphological defects and cardiac dysfunction in zebrafish embryos, manifesting symptoms similar to systolic heart failure. The etiology of BuP-induced systolic heart failure in zebrafish embryos is multifactorial, including cardiomyocyte apoptosis, endocardial and atrioventricular valve damage, insufficient myocardial energy, impaired Ca2+ homeostasis, depletion of cardiac-resident macrophages, cardiac immune non-responsiveness, and cardiac oxidative stress. However, excessive accumulation of reactive oxygen species (ROS) in the cardiac region and cardiac immunosuppression (depletion of cardiac-resident macrophages and cardiac immune non-responsiveness) may be the predominant factors. In conclusion, this study indicates that BuP is a potential hazardous substance that can cause adverse effects on the developing heart and provides evidence and insights into the pathological mechanisms by which BuP leads to cardiac dysfunction. It may help to prevent the BuP-based congenital heart disease heart failure in human through ameliorating strategies and BuP discharge policies, while raising awareness to prevent the misuse of preservatives. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S014765132301196X; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2023.115692 |
| URL الوصول: | https://doaj.org/article/2e70bbc700c5489e899d6b2d0146ee05 |
| رقم الأكسشن: | edsdoj.2e70bbc700c5489e899d6b2d0146ee05 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2023.115692 |