دورية أكاديمية
Using the fast fourier transform to accelerate the computational search for RNA conformational switches.
| العنوان: | Using the fast fourier transform to accelerate the computational search for RNA conformational switches. |
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| المؤلفون: | Evan Senter, Saad Sheikh, Ivan Dotu, Yann Ponty, Peter Clote |
| المصدر: | PLoS ONE, Vol 7, Iss 12, p e50506 (2012) |
| بيانات النشر: | Public Library of Science (PLoS), 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Using complex roots of unity and the Fast Fourier Transform, we design a new thermodynamics-based algorithm, FFTbor, that computes the Boltzmann probability that secondary structures differ by [Formula: see text] base pairs from an arbitrary initial structure of a given RNA sequence. The algorithm, which runs in quartic time O(n(4)) and quadratic space O(n(2)), is used to determine the correlation between kinetic folding speed and the ruggedness of the energy landscape, and to predict the location of riboswitch expression platform candidates. A web server is available at http://bioinformatics.bc.edu/clotelab/FFTbor/. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23284639/?tool=EBI; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0050506 |
| URL الوصول: | https://doaj.org/article/2e7cf30e770a41ba88b630c8ce791991 |
| رقم الأكسشن: | edsdoj.2e7cf30e770a41ba88b630c8ce791991 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0050506 |