دورية أكاديمية
Small-Molecule Modulation of PPARs for the Treatment of Prevalent Vascular Retinal Diseases
| العنوان: | Small-Molecule Modulation of PPARs for the Treatment of Prevalent Vascular Retinal Diseases |
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| المؤلفون: | Xiaozheng Dou, Adam S. Duerfeldt |
| المصدر: | International Journal of Molecular Sciences, Vol 21, Iss 23, p 9251 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, peroxisome proliferator-activated receptor, drug discovery, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Vascular-related retinal diseases dramatically impact quality of life and create a substantial burden on the healthcare system. Age-related macular degeneration, diabetic retinopathy, and retinopathy of prematurity are leading causes of irreversible blindness. In recent years, the scientific community has made great progress in understanding the pathology of these diseases and recent discoveries have identified promising new treatment strategies. Specifically, compelling biochemical and clinical evidence is arising that small-molecule modulation of peroxisome proliferator-activated receptors (PPARs) represents a promising approach to simultaneously address many of the pathological drivers of these vascular-related retinal diseases. This has excited academic and pharmaceutical researchers towards developing new and potent PPAR ligands. This review highlights recent developments in PPAR ligand discovery and discusses the downstream effects of targeting PPARs as a therapeutic approach to treating retinal vascular diseases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/21/23/9251; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms21239251 |
| URL الوصول: | https://doaj.org/article/2e9b4e639b9a4106825c4ae3669c6608 |
| رقم الأكسشن: | edsdoj.2e9b4e639b9a4106825c4ae3669c6608 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms21239251 |