دورية أكاديمية
أعرض في EDS

Positive outcomes influence the rate and time to publication, but not the impact factor of publications of clinical trial results.

التفاصيل البيبلوغرافية
العنوان: Positive outcomes influence the rate and time to publication, but not the impact factor of publications of clinical trial results.
المؤلفون: Pilar Suñé, Josep Maria Suñé, J Bruno Montoro
المصدر: PLoS ONE, Vol 8, Iss 1, p e54583 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: OBJECTIVES: Publication bias may affect the validity of evidence based medical decisions. The aim of this study is to assess whether research outcomes affect the dissemination of clinical trial findings, in terms of rate, time to publication, and impact factor of journal publications. METHODS AND FINDINGS: All drug-evaluating clinical trials submitted to and approved by a general hospital ethics committee between 1997 and 2004 were prospectively followed to analyze their fate and publication. Published articles were identified by searching Pubmed and other electronic databases. Clinical study final reports submitted to the ethics committee, final reports synopses available online and meeting abstracts were also considered as sources of study results. Study outcomes were classified as positive (when statistical significance favoring experimental drug was achieved), negative (when no statistical significance was achieved or it favored control drug) and descriptive (for non-controlled studies). Time to publication was defined as time from study closure to publication. A survival analysis was performed using a Cox regression model to analyze time to publication. Journal impact factors of identified publications were recorded. Publication rate was 48·4% (380/785). Study results were identified for 68·9% of all completed clinical trials (541/785). Publication rate was 84·9% (180/212) for studies with results classified as positive and 68·9% (128/186) for studies with results classified as negative (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3559840?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0054583
URL الوصول: https://doaj.org/article/2ec423aef5bf473d86897c53a8e4418a
رقم الأكسشن: edsdoj.2ec423aef5bf473d86897c53a8e4418a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0054583