دورية أكاديمية
Successful treatment of invasive mycobacterium infection with interferon beta in a patient with Interferon-Gamma Receptor 1 deficiency
| العنوان: | Successful treatment of invasive mycobacterium infection with interferon beta in a patient with Interferon-Gamma Receptor 1 deficiency |
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| المؤلفون: | Fayhan Alroqi, Abduarahman Almutairi, Moza Alhammadi, Shatha Alhamdi |
| المصدر: | Journal of Infection and Public Health, Vol 17, Iss 8, Pp 102468- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Infectious and parasitic diseases LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Mendelian susceptibility to mycobacterial disease (MSMD), Interferon-Gamma Receptor 1 deficiency (IFNGR1 deficiency), Interferon- Beta (IFN-β), Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270 |
| الوصف: | Mendelian susceptibility to mycobacterial disease (MSMD) is caused by approximately 21 genetic defects, including a mutation in Interferon-Gamma Receptor 1 (IFNGR1). IFNGR1 deficiency leads to a loss of cellular responsiveness to type II Interferon (IFN-γ), which plays a significant role in controlling intracellular bacteria. This study explored the response of IFN–β therapy in a patient with partial IFNGR1 deficiency to treat invasive mycobacterial infection. The biological therapy was used successfully as an adjuvant to anti-mycobacterial medications to treat a 17-year-old girl with partial IFNGR1 deficiency who presented with a recurrent mycobacterial infection that extended to her central nervous system, which resulted in clinical and radiological improvement. This report suggests that activation of type I IFN through Signal Transducers and Activators of Transcription1 (STAT1) could bypass the early IFN-γ signaling defects and activate IFN-γ production. For that reason, IFN–β might be used as a beneficial adjuvant therapy for managing extensive central nervous system mycobacterial infection, especially in patients with IFNGR1 deficiency. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1876-0341 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1876034124002028; https://doaj.org/toc/1876-0341 |
| DOI: | 10.1016/j.jiph.2024.102468 |
| URL الوصول: | https://doaj.org/article/2ec4f7e1c00a426685d0390138c5cf9a |
| رقم الأكسشن: | edsdoj.2ec4f7e1c00a426685d0390138c5cf9a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 18760341 |
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| DOI: | 10.1016/j.jiph.2024.102468 |