دورية أكاديمية
Different Tumour Marker Kinetics as Prognosticators in Patients with Adenocarcinoma of Gall Bladder Undergoing Chemotherapy: A Cohort Study
| العنوان: | Different Tumour Marker Kinetics as Prognosticators in Patients with Adenocarcinoma of Gall Bladder Undergoing Chemotherapy: A Cohort Study |
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| المؤلفون: | Pritilata saha, Priyanka Datta, Quazi Md Tajuddin, Subhramay Chatterjee |
| المصدر: | National Journal of Laboratory Medicine, Vol 13, Iss 03, Pp 16-21 (2024) |
| بيانات النشر: | JCDR Research and Publications Pvt. Ltd., 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Microbiology LCC:Chemistry |
| مصطلحات موضوعية: | gallbladder cancer, metastasis, prognostic marker, serum carbohydrate antigen, Microbiology, QR1-502, Chemistry, QD1-999 |
| الوصف: | Introduction: Gallbladder Cancer (GBC) is the most common malignancy of the biliary tract worldwide. Patients do not have specific symptoms, and therefore, GBC is usually diagnosed at an advanced stage. Carbohydrate Antigen (CA)-242, CA 19-9, and Cancer Antigen 125 (CA-125) have been found to be effective in the diagnosis and prognosis of GBC. Aim: To determine the significance of tumour markers as prognosticators in adenocarcinoma of GBC with chemotherapy. Materials and Methods: The present cohort study was conducted in the Department of Biochemistry, Murshidabad Medical College and Hospital, Baharampur, West Bengal, India, between December 2021 and November 2022. Thirty patients with pathologically confirmed adenocarcinoma of the gallbladder who were treated with gemcitabine-based chemotherapy were included in the study. Differences in serum CA-125 and CA 19-9 levels before and after chemotherapy (KINETICS) were measured along with haemoglobin, serum urea, creatinine, total bilirubin and Neutrophil-Lymphocyte Ratio (NLR). Receiver Operating Characteristic (ROC) curve analysis and Kaplan-Meier analyses of CA-125, CA 19-9, and combined changes were performed to assess survival rates and their statistical relevance as prognosticators in correlation with disease progression. Results: The mean±Standard Deviation (SD) age was 52.4±5.275 years. A total of 25 (83.3%) patients were females. The associations of CA 19-9 change with other baseline variables were analysed, and there were significant associations with baseline Carbohydrate Antigen (CA19-9) levels (p-value=0.003) and metastatic changes (p-value |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2277-8551 2455-6882 |
| Relation: | https://www.njlm.net/articles/PDF/2866/69610_CE[Ra1]_F(SHU)_QC(AN_RDW_IS)_PF1(JY_SHU_OM)_redo_PFA(SHU)_PB(JY_SHU)_PN(SHU).pdf; https://doaj.org/toc/2277-8551; https://doaj.org/toc/2455-6882 |
| DOI: | 10.7860/NJLM/2024/69610.2866 |
| URL الوصول: | https://doaj.org/article/2efdeb9782f64db9b4b96e6383836e0f |
| رقم الأكسشن: | edsdoj.2efdeb9782f64db9b4b96e6383836e0f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22778551 24556882 |
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| DOI: | 10.7860/NJLM/2024/69610.2866 |