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Budesonide Analogues Preserve Stem Cell Pluripotency and Delay 3D Gastruloid Development

التفاصيل البيبلوغرافية
العنوان: Budesonide Analogues Preserve Stem Cell Pluripotency and Delay 3D Gastruloid Development
المؤلفون: Filomena Amoroso, Eduardo Ibello, Federica Saracino, Federica Cermola, Giovanna Ponticelli, Enrica Scalera, Francesca Ricci, Gino Villetti, Gilda Cobellis, Gabriella Minchiotti, Eduardo Jorge Patriarca, Dario De Cesare, Cristina D’Aniello
المصدر: Pharmaceutics, Vol 15, Iss 7, p 1897 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Pharmacy and materia medica
مصطلحات موضوعية: drug toxicity, budesonide analogues, stem cells, pluripotency exit, 3D gastruloids, Pharmacy and materia medica, RS1-441
الوصف: Small molecules that can modulate or stabilize cell–cell interactions are valuable tools for investigating the impact of collective cell behavior on various biological processes such as development/morphogenesis, tissue regeneration and cancer progression. Recently, we showed that budesonide, a glucocorticoid widely used as an anti-asthmatic drug, is a potent regulator of stem cell pluripotency. Here we tested the effect of different budesonide derivatives and identified CHD-030498 as a more effective analogue of budesonide. CHD-030498 was able to prevent stem cell pluripotency exit in different cell-based models, including embryonic stem-to-mesenchymal transition, spontaneous differentiation and 3D gastruloid development, and at lower doses compared to budesonide.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1999-4923
50148117
Relation: https://www.mdpi.com/1999-4923/15/7/1897; https://doaj.org/toc/1999-4923
DOI: 10.3390/pharmaceutics15071897
URL الوصول: https://doaj.org/article/2f2a501481174f1b98902d8d9fa73017
رقم الأكسشن: edsdoj.2f2a501481174f1b98902d8d9fa73017
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19994923
50148117
DOI:10.3390/pharmaceutics15071897