دورية أكاديمية
Hematopoietic Stem Cells and Their Niche in Bone Marrow
| العنوان: | Hematopoietic Stem Cells and Their Niche in Bone Marrow |
|---|---|
| المؤلفون: | Munju Kwon, Byoung Soo Kim, Sik Yoon, Sae-Ock Oh, Dongjun Lee |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 13, p 6837 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | hematopoietic stem cells, hematopoietic progenitor cells, bone marrow microenvironment, niche, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Extensive research has explored the functional correlation between stem cells and progenitor cells, particularly in blood. Hematopoietic stem cells (HSCs) can self-renew and regenerate tissues within the bone marrow, while stromal cells regulate tissue function. Recent studies have validated the role of mammalian stem cells within specific environments, providing initial empirical proof of this functional phenomenon. The interaction between bone and blood has always been vital to the function of the human body. It was initially proposed that during evolution, mammalian stem cells formed a complex relationship with the surrounding microenvironment, known as the niche. Researchers are currently debating the significance of molecular-level data to identify individual stromal cell types due to incomplete stromal cell mapping. Obtaining these data can help determine the specific activities of HSCs in bone marrow. This review summarizes key topics from previous studies on HSCs and their environment, discussing current and developing concepts related to HSCs and their niche in the bone marrow. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/25/13/6837; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms25136837 |
| URL الوصول: | https://doaj.org/article/2f43a7fe1d264b4d9ae39bfb3403e9d3 |
| رقم الأكسشن: | edsdoj.2f43a7fe1d264b4d9ae39bfb3403e9d3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms25136837 |