دورية أكاديمية
Ultrarapid Iron Polymaltose Infusions Are Safe for Management of Iron Deficiency
| العنوان: | Ultrarapid Iron Polymaltose Infusions Are Safe for Management of Iron Deficiency |
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| المؤلفون: | Iouri Banakh, Martha Turek, Daniel Niewodowski, Rumes Kanna Sriamareswaran, Fiona Yeaman, Lilian Vo, Travis Churchill |
| المصدر: | GE: Portuguese Journal of Gastroenterology, Pp 1-9 (2023) |
| بيانات النشر: | Karger Publishers, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | iron deficiency, iron infusion, safety, treatment and hospital, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Introduction: Iron deficiency is a common condition, especially among patients with kidney and heart failure and inflammatory bowel disease. Intravenous iron is the preferred method of treatment in these patients, but it usually requires prolonged iron polymaltose infusions or multiple administrations of alternative preparations. The aim of the study was to confirm the safety and patient acceptance of ultrarapid iron polymaltose infusions as an alternative to slower treatments and ferric carboxymaltose. Method: An open-label, phase 4 safety study was conducted at a tertiary hospital, with consenting participants diagnosed with iron deficiency and requiring iron polymaltose up to 1,500 mg receiving the infusion over 15 min. The acute adverse event (AE) rates and their severities were compared to historical controls of 1- and 4-h iron polymaltose infusions from a retrospective study of 648 patients from the same study site. Delayed AEs as well as participant infusion acceptability were also studied. Results: Three hundred participants over a 2-year period received ultrarapid infusions of iron polymaltose with an acute AE rate of 18.7% and severe AE rate of 1.0%. The total and mild infusion AE rates were higher compared to those of slower infusions (p < 0.001), but comparable for moderate and severe AEs. Delayed reactions occurred in 12.5% of participants, with over 95% of them preferring repeat ultrarapid infusions if required again. Conclusion: Iron polymaltose can be safely infused at ultrarapid rates when compared to slower infusions, with similar safety to ferric carboxymaltose, offering greater convenience for patients and reduced healthcare costs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2341-4545 2387-1954 00052779 |
| Relation: | https://www.karger.com/Article/FullText/527794; https://doaj.org/toc/2341-4545; https://doaj.org/toc/2387-1954 |
| DOI: | 10.1159/000527794 |
| URL الوصول: | https://doaj.org/article/2f46af4face9465e8076fd85a3ebaf2a |
| رقم الأكسشن: | edsdoj.2f46af4face9465e8076fd85a3ebaf2a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23414545 23871954 00052779 |
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| DOI: | 10.1159/000527794 |