دورية أكاديمية
Vogt-koyanagi-harada syndrome - A neurologist's perspective
| العنوان: | Vogt-koyanagi-harada syndrome - A neurologist's perspective |
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| المؤلفون: | Sumanth Shivaram, Madhu Nagappa, Doniparthi V Seshagiri, Jayanth Shimoga Shanthakumar, Swayang Sudha Panda, Ravi Anadure, B N Nandeesh, Yasha T Chickabasaviah, Rose D Bharath, Joy Vijayan, Bakula Kashyap, Sanjib Sinha, Arun B Taly |
| المصدر: | Annals of Indian Academy of Neurology, Vol 24, Iss 3, Pp 405-409 (2021) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: | aseptic meningitis, brain-eye-ear (bee) syndromes, exudative retinal detachment, melanin-laden macrophages, poliosis, vogt-koyanagi-harada syndrome, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: | Vogt-Koyanagi-Harada (VKH) syndrome is an immune-mediated granulomatous disease which affects melanin-rich organs like eyes, skin, nervous system, and ears. Neurological and auditory manifestations usually precede the involvement of other sites. Patients may manifest with “complete” or “incomplete” syndrome. We report two patients who presented with acute headache and impaired vision. Fundus examination revealed optic disc hyperemia and exudative retinal detachment which provided a clue for the diagnosis at the bedside. Fundus fluorescein angiogram (FFA) revealed abnormal dye leakage, whereas B scan showed choroid thickening. Cerebrospinal fluid (CSF) pleocytosis contrasted with unremarkable brain magnetic resonance imaging and lack of meningeal signs. Melanophagocytosis was evidenced by melanin-laden macrophages in CSF and skin biopsy. This finding is specific for VKH syndrome and helps to clinch the diagnosis even when the complete syndrome is not present cross-sectionally. VKH syndrome should be suspected in patients with aseptic meningitis if tests for common infectious and immune-mediated diseases are negative. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0972-2327 1998-3549 |
| Relation: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2021;volume=24;issue=3;spage=405;epage=409;aulast=Shivaram; https://doaj.org/toc/0972-2327; https://doaj.org/toc/1998-3549 |
| DOI: | 10.4103/aian.AIAN_405_20 |
| URL الوصول: | https://doaj.org/article/d2f72c93ca914e779d06262c0f0c161d |
| رقم الأكسشن: | edsdoj.2f72c93ca914e779d06262c0f0c161d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09722327 19983549 |
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| DOI: | 10.4103/aian.AIAN_405_20 |