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NFATc1 regulates the transcription of DNA damage-induced apoptosis suppressor

التفاصيل البيبلوغرافية
العنوان: NFATc1 regulates the transcription of DNA damage-induced apoptosis suppressor
المؤلفون: Joo-Young Im, Kang-Woo Lee, Kyoung-Jae Won, Bo-Kyung Kim, Hyun Seung Ban, Sung-Hoon Yoon, Young-Ju Lee, Young-Joo Kim, Kyung-Bin Song, Misun Won
المصدر: Data in Brief, Vol 5, Iss C, Pp 975-980 (2015)
بيانات النشر: Elsevier, 2015.
سنة النشر: 2015
المجموعة: LCC:Computer applications to medicine. Medical informatics
LCC:Science (General)
مصطلحات موضوعية: DDIAS, NFATc1, ChIP, Lung cancer, Pancreatic cancer, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390
الوصف: DNA damage induced apoptosis suppressor (DDIAS), or human Noxin (hNoxin), is strongly expressed in lung cancers. DDIAS knockdown induced apoptosis in non-small cell lung carcinoma A549 cells in response to DNA damage, indicating DDIAS as a potential therapeutic target in lung cancer. To understand the transcriptional regulation of DDIAS, we determined the transcription start site, promoter region, and transcription factor. We found that DDIAS transcription begins at nucleotide 212 upstream of the DDIAS translation start site. We cloned the DDIAS promoter region and identified NFAT2 as a major transcription factor (Im et al., 2016 [1]). We demonstrated that NFATc1 regulates DDIAS expression in both pancreatic cancer Panc-1 cells and lung cancer cells.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2352-3409
Relation: http://www.sciencedirect.com/science/article/pii/S2352340915003066; https://doaj.org/toc/2352-3409
DOI: 10.1016/j.dib.2015.11.011
URL الوصول: https://doaj.org/article/e2f91985ef824cc5a992dc7e88eeeebe
رقم الأكسشن: edsdoj.2f91985ef824cc5a992dc7e88eeeebe
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23523409
DOI:10.1016/j.dib.2015.11.011