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Postbiotic potential of Bacillus velezensis KMU01 cell-free supernatant for the alleviation of obesity in mice

التفاصيل البيبلوغرافية
العنوان: Postbiotic potential of Bacillus velezensis KMU01 cell-free supernatant for the alleviation of obesity in mice
المؤلفون: Hee Hyun Shin, Jong-Hoon Kim, Ye-Jin Jung, Mi-Sun Kwak, Moon-Hee Sung, Jee-Young Imm
المصدر: Heliyon, Vol 10, Iss 5, Pp e25263- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Science (General)
LCC:Social sciences (General)
مصطلحات موضوعية: Obesity, Bacillus velezensis KMU01, Cell-free supernatant, Gut microbiome, Science (General), Q1-390, Social sciences (General), H1-99
الوصف: Attention toward the preventive effects of postbiotics on metabolic diseases has increased because of greater stability and safety over probiotics. However, studies regarding the bioactive effects of postbiotics, especially from probiotic Bacillus strains, are relatively limited. The anti-obesity effects of the cell-free culture supernatant of Bacillus velezensis KMU01 (CFS–B.vele) were evaluated using high-fat-diet (HFD)-induced mice. HFD-induced mice (n = 8 per group) received equal volumes of (1) CFS-B.vele (114 mg/kg) in PBS, (2) Xenical in PBS, or (3) PBS alone by oral gavage daily for 13 weeks. The results demonstrated that CFS-B.vele changed the gut microbiota and showed anti-obesity effects in HFD-induced obese mice. The elevated Firmicutes/Bacteroidota ratio induced by HFD was decreased in the CFS-B.vele group compared to the other groups (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-8440
Relation: http://www.sciencedirect.com/science/article/pii/S2405844024012945; https://doaj.org/toc/2405-8440
DOI: 10.1016/j.heliyon.2024.e25263
URL الوصول: https://doaj.org/article/e2f98812508044e59b769632b3d68e62
رقم الأكسشن: edsdoj.2f98812508044e59b769632b3d68e62
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24058440
DOI:10.1016/j.heliyon.2024.e25263