دورية أكاديمية

Mathematical modelling of the interactive dynamics of wild and Microsporidia MB-infected mosquitoes

التفاصيل البيبلوغرافية
العنوان: Mathematical modelling of the interactive dynamics of wild and Microsporidia MB-infected mosquitoes
المؤلفون: Charlène N. T. Mfangnia, Henri E. Z. Tonnang, Berge Tsanou, Jeremy Herren
المصدر: Mathematical Biosciences and Engineering, Vol 20, Iss 8, Pp 15167-15200 (2023)
بيانات النشر: AIMS Press, 2023.
سنة النشر: 2023
المجموعة: LCC:Biotechnology
LCC:Mathematics
مصطلحات موضوعية: microsporidia mb, plasmodium transmission-blocking, vertical-horizontal transmission, compartmental modelling, seasonality, malaria bio-control, Biotechnology, TP248.13-248.65, Mathematics, QA1-939
الوصف: A recent discovery highlighted that mosquitoes infected with Microsporidia MB are unable to transmit the Plasmodium to humans. Microsporidia MB is a symbiont transmitted vertically and horizontally in the mosquito population, and these transmission routes are known to favor the persistence of the parasite in the mosquito population. Despite the dual transmission, data from field experiments reveal a low prevalence of MB-infected mosquitoes in nature. This study proposes a compartmental model to understand the prevalence of MB-infected mosquitoes. The dynamic of the model is obtained through the computation of the basic reproduction number and the analysis of the stability of the MB-free and coexistence equilibria. The model shows that, in spite of the high vertical transmission efficiency of Microsporidia MB, there can still be a low prevalence of MB-infected mosquitoes. Numerical analysis of the model shows that male-to-female horizontal transmission contributes more than female-to-male horizontal transmission to the spread of MB-infected mosquitoes. Moreover, the female-to-male horizontal transmission contributes to the spread of the symbiont only if there are multiple mating occurrences for male mosquitoes. Furthermore, when fixing the efficiencies of vertical transmission, the parameters having the greater influence on the ratio of MB-positive to wild mosquitoes are identified. In addition, by assuming a similar impact of the temperature on wild and MB-infected mosquitoes, our model shows the seasonal fluctuation of MB-infected mosquitoes. This study serves as a reference for further studies, on the release strategies of MB-infected mosquitoes, to avoid overestimating the MB-infection spread.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1551-0018
Relation: https://doaj.org/toc/1551-0018
DOI: 10.3934/mbe.2023679?viewType=HTML
DOI: 10.3934/mbe.2023679
URL الوصول: https://doaj.org/article/2fa83a0aa6ff4ee39faedce151599921
رقم الأكسشن: edsdoj.2fa83a0aa6ff4ee39faedce151599921
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:15510018
DOI:10.3934/mbe.2023679?viewType=HTML