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The PPAR Gamma Agonist Troglitazone Regulates Erk 1/2 Phosphorylation via a PPARγ-Independent, MEK-Dependent Pathway in Human Prostate Cancer Cells

التفاصيل البيبلوغرافية
العنوان: The PPAR Gamma Agonist Troglitazone Regulates Erk 1/2 Phosphorylation via a PPARγ-Independent, MEK-Dependent Pathway in Human Prostate Cancer Cells
المؤلفون: Adrienne Bolden, Lynikka Bernard, Danielle Jones, Tunde Akinyeke, LaMonica V. Stewart
المصدر: PPAR Research, Vol 2012 (2012)
بيانات النشر: Wiley, 2012.
سنة النشر: 2012
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: Biology (General), QH301-705.5
الوصف: Thiazolidinediones (TZDs) dramatically reduce the growth of human prostate cancer cells in vitro and in vivo. To determine whether the antitumor effects of TZDs were due in part to changes in the MEK/Erk signaling pathway, we examined the regulation of Erk phosphorylation by the TZD troglitazone within the PC-3 and C4-2 human prostate cancer cell lines. Western blot analysis revealed troglitazone-induced phosphorylation of Erk in both PC-3 and C4-2 cells. Troglitazone-induced increases in Erk phosphorylation were suppressed by the MEK inhibitor U0126 but not by the PPARγ antagonist GW9662. Pretreatment with U0126 did not alter the ability of troglitazone to regulate expression of two proteins that control cell cycle, p21, and c-Myc. Troglitazone was also still effective at reducing PC-3 proliferation in the presence of U0126. Therefore, our data suggest that troglitazone-induced Erk phosphorylation does not significantly contribute to the antiproliferative effect of troglitazone.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1687-4757
1687-4765
Relation: https://doaj.org/toc/1687-4757; https://doaj.org/toc/1687-4765
DOI: 10.1155/2012/929052
URL الوصول: https://doaj.org/article/2fcd54810502460bbfb52ba44e109896
رقم الأكسشن: edsdoj.2fcd54810502460bbfb52ba44e109896
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:16874757
16874765
DOI:10.1155/2012/929052