دورية أكاديمية
أعرض في EDS

The Protective Role of Carnosic Acid against Beta-Amyloid Toxicity in Rats

التفاصيل البيبلوغرافية
العنوان: The Protective Role of Carnosic Acid against Beta-Amyloid Toxicity in Rats
المؤلفون: H. Rasoolijazi, N. Azad, M. T. Joghataei, M. Kerdari, F. Nikbakht, M. Soleimani
المصدر: The Scientific World Journal, Vol 2013 (2013)
بيانات النشر: Wiley, 2013.
سنة النشر: 2013
المجموعة: LCC:Technology
LCC:Medicine
LCC:Science
مصطلحات موضوعية: Technology, Medicine, Science
الوصف: Oxidative stress is one of the pathological mechanisms responsible for the beta- amyloid cascade associated with Alzheimer’s disease (AD). Previous studies have demonstrated the role of carnosic acid (CA), an effective antioxidant, in combating oxidative stress. A progressive cognitive decline is one of the hallmarks of AD. Thus, we attempted to determine whether the administration of CA protects against memory deficit caused by beta-amyloid toxicity in rats. Beta-amyloid (1–40) was injected by stereotaxic surgery into the Ca1 region of the hippocampus of rats in the Amyloid beta (Aβ) groups. CA was delivered intraperitoneally, before and after surgery in animals in the CA groups. Passive avoidance learning and spontaneous alternation behavior were evaluated using the shuttle box and the Y-maze, respectively. The degenerating hippocampal neurons were detected by fluoro-jade b staining. We observed that beta-amyloid (1–40) can induce neurodegeneration in the Ca1 region of the hippocampus by using fluoro-jade b staining. Also, the behavioral tests revealed that CA may recover the passive avoidance learning and spontaneous alternation behavior scores in the Aβ + CA group, in comparison with the Aβ group. We found that CA may ameliorate the spatial and learning memory deficits induced by the toxicity of beta-amyloid in the rat hippocampus.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1537-744X
Relation: https://doaj.org/toc/1537-744X
DOI: 10.1155/2013/917082
URL الوصول: https://doaj.org/article/2fec50361fbe4e1084753fe84d75fc3e
رقم الأكسشن: edsdoj.2fec50361fbe4e1084753fe84d75fc3e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1537744X
DOI:10.1155/2013/917082