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أعرض في EDS

Prevalence of Pulmonary Hypertension in the General Population: The Rotterdam Study.

التفاصيل البيبلوغرافية
العنوان: Prevalence of Pulmonary Hypertension in the General Population: The Rotterdam Study.
المؤلفون: Eduardo M Moreira, Henning Gall, Maarten J G Leening, Lies Lahousse, Daan W Loth, Bouwe P Krijthe, Jessica C Kiefte-de Jong, Guy G Brusselle, Albert Hofman, Bruno H Stricker, Hossein A Ghofrani, Oscar H Franco, Janine F Felix
المصدر: PLoS ONE, Vol 10, Iss 6, p e0130072 (2015)
بيانات النشر: Public Library of Science (PLoS), 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Pulmonary hypertension is characterized by increased pulmonary artery pressure and carries an increased mortality. Population-based studies into pulmonary hypertension are scarce and little is known about its prevalence in the general population. We aimed to describe the distribution of echocardiographically-assessed pulmonary artery systolic pressure (ePASP) in the general population, to estimate the prevalence of pulmonary hypertension, and to identify associated factors.Participants (n = 3381, mean age 76.4 years, 59% women) from the Rotterdam Study, a population-based cohort, underwent echocardiography. Echocardiographic pulmonary hypertension was defined as ePASP>40 mmHg.Mean ePASP was 26.3 mmHg (SD 7.0). Prevalence of echocardiographic pulmonary hypertension was 2.6% (95%CI: 2.0; 3.2). Prevalence was higher in older participants compared to younger ones (8.3% in those over 85 years versus 0.8% in those between 65 and 70), and in those with underlying disorders versus those without (5.9% in subjects with COPD versus 2.3%; 9.2% in those with left ventricular systolic dysfunction versus 2.3%; 23.1% in stages 3 or 4 left ventricular diastolic dysfunction versus 1.9% in normal or stage 1). Factors independently associated with higher ePASP were older age, higher BMI, left ventricular diastolic dysfunction, COPD and systemic hypertension.In this large population-based study, we show that pulmonary hypertension as measured by echocardiography has a low prevalence in the overall general population in the Netherlands, but estimates may be higher in specific subgroups, especially in those with underlying diseases. Increased pulmonary arterial pressure is likely to gain importance in the near future due to population aging and the accompanying prevalences of underlying disorders.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4478029?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0130072
URL الوصول: https://doaj.org/article/c2ff1541df524b48a017661df572ef26
رقم الأكسشن: edsdoj.2ff1541df524b48a017661df572ef26
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0130072