دورية أكاديمية
Prognostic and Predictive Roles of KRAS Mutation in Colorectal Cancer
| العنوان: | Prognostic and Predictive Roles of KRAS Mutation in Colorectal Cancer |
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| المؤلفون: | Amanda K. Arrington, Eileen L. Heinrich, Wendy Lee, Marjun Duldulao, Supriya Patel, Julian Sanchez, Julio Garcia-Aguilar, Joseph Kim |
| المصدر: | International Journal of Molecular Sciences, Vol 13, Iss 10, Pp 12153-12168 (2012) |
| بيانات النشر: | MDPI AG, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | KRAS, colorectal cancer, colon cancer, EGFR, Let7, ras, oncogenes, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The RAS gene family is among the most studied and best characterized of the known cancer-related genes. Of the three human ras isoforms, KRAS is the most frequently altered gene, with mutations occurring in 17%–25% of all cancers. In particular, approximately 30%–40% of colon cancers harbor a KRAS mutation. KRAS mutations in colon cancers have been associated with poorer survival and increased tumor aggressiveness. Additionally, KRAS mutations in colorectal cancer lead to resistance to select treatment strategies. In this review we examine the history of KRAS, its prognostic value in patients with colorectal cancer, and evidence supporting its predictive value in determining appropriate therapies for patients with colorectal cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | http://www.mdpi.com/1422-0067/13/10/12153; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms131012153 |
| URL الوصول: | https://doaj.org/article/2ffb700fb5f44617987a9908377fe67d |
| رقم الأكسشن: | edsdoj.2ffb700fb5f44617987a9908377fe67d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms131012153 |