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A Refined Multiscale Self-Entropy Approach for the Assessment of Cardiac Control Complexity: Application to Long QT Syndrome Type 1 Patients

التفاصيل البيبلوغرافية
العنوان: A Refined Multiscale Self-Entropy Approach for the Assessment of Cardiac Control Complexity: Application to Long QT Syndrome Type 1 Patients
المؤلفون: Vlasta Bari, Giulia Girardengo, Andrea Marchi, Beatrice De Maria, Paul A. Brink, Lia Crotti, Peter J. Schwartz, Alberto Porta
المصدر: Entropy, Vol 17, Iss 11, Pp 7768-7785 (2015)
بيانات النشر: MDPI AG, 2015.
سنة النشر: 2015
المجموعة: LCC:Science
LCC:Astrophysics
LCC:Physics
مصطلحات موضوعية: information storage, heart rate variability, QT interval, refined multiscale entropy, LQT1, corrected conditional entropy, KCNQ1-A341V mutation, autonomic nervous system, Science, Astrophysics, QB460-466, Physics, QC1-999
الوصف: The study proposes the contemporaneous assessment of conditional entropy (CE) and self-entropy (sE), being the two terms of the Shannon entropy (ShE) decomposition, as a function of the time scale via refined multiscale CE (RMSCE) and sE (RMSsE) with the aim at gaining insight into cardiac control in long QT syndrome type 1 (LQT1) patients featuring the KCNQ1-A341V mutation. CE was estimated via the corrected CE (CCE) and sE as the difference between the ShE and CCE. RMSCE and RMSsE were computed over the beat-to-beat series of heart period (HP) and QT interval derived from 24-hour Holter electrocardiographic recordings during daytime (DAY) and nighttime (NIGHT). LQT1 patients were subdivided into asymptomatic and symptomatic mutation carriers (AMCs and SMCs) according to the severity of symptoms and contrasted with non-mutation carriers (NMCs). We found that RMSCE and RMSsE carry non-redundant information, separate experimental conditions (i.e., DAY and NIGHT) within a given group and distinguish groups (i.e., NMC, AMC and SMC) assigned the experimental condition. Findings stress the importance of the joint evaluation of RMSCE and RMSsE over HP and QT variabilities to typify the state of the autonomic function and contribute to clarify differences between AMCs and SMCs.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1099-4300
Relation: http://www.mdpi.com/1099-4300/17/11/7768; https://doaj.org/toc/1099-4300
DOI: 10.3390/e17117768
URL الوصول: https://doaj.org/article/e30004f091a4459aae30bc1f989e9d98
رقم الأكسشن: edsdoj.30004f091a4459aae30bc1f989e9d98
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:10994300
DOI:10.3390/e17117768