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Astragaloside IV alleviates heart failure by promoting angiogenesis through the JAK-STAT3 pathway

التفاصيل البيبلوغرافية
العنوان: Astragaloside IV alleviates heart failure by promoting angiogenesis through the JAK-STAT3 pathway
المؤلفون: Yan-Bo Sui, Yu Wang, Li Liu, Feng Liu, Yi-Qing Zhang
المصدر: Pharmaceutical Biology, Vol 57, Iss 1, Pp 48-54 (2019)
بيانات النشر: Taylor & Francis Group, 2019.
سنة النشر: 2019
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: left coronary artery ligation, cd31, vegf, rna interference, Therapeutics. Pharmacology, RM1-950
الوصف: Context: Heart failure (HF) is one of the most serious diseases worldwide. Astragaloside IV (ASI) is widely used for the treatment of cardiovascular disease in China. Objective: To evaluate the protective effect of ASI on the HF in a Sprague–Dawley rat model of left coronary artery ligation, and investigate the angiogenesis-related mechanisms. Materials and methods: Left coronary artery was ligated to induce a rat model of HF, and the rats were treated with vehicle (saline) or different doses of ASI (0.1, 0.3 and 1 mg/kg/day) by oral gavage for 6 weeks. Cardiac function was evaluated by echocardiography. Infarct size was determined by triphenyltetrazolium chloride staining. Cardiac vascular density was analyzed by microangiography. Real-time PCR, Western blot and chromatin immunoprecipitation were performed to investigate the mechanisms. Results: ASI treatment improved the body weight and survival rate of HF rats, as well as the cardiac function of HF rats, with significantly improved ejection fraction (75.27 ± 5.75% vs. 36.26 ± 4.14%) and fractional shortening (45.39 ± 3.66% vs. 17.88 ± 1.32%). ASI reduced the infarct size of the HF rats by 47%. ASI promoted angiogenesis, with increased vascular density (2.08-fold) and induced mRNA expression of CD31 (1.81-fold) and VEGF (2.70-fold) in the ischemic heart. Furthermore, ASI induced the phosphorylation of JAK (1.89-fold) and STAT3 (2.95-fold), as well as the activity of VEGF promoter which was regulated by STAT3. Discussion and conclusions: ASI alleviated HF by promoting angiogenesis through JAK-STAT3 pathway, providing novel alternative strategies to prevent HF in the future.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1388-0209
1744-5116
13880209
Relation: https://doaj.org/toc/1388-0209; https://doaj.org/toc/1744-5116
DOI: 10.1080/13880209.2019.1569697
URL الوصول: https://doaj.org/article/30fc41ab8e72464fab9085b4d9139a56
رقم الأكسشن: edsdoj.30fc41ab8e72464fab9085b4d9139a56
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:13880209
17445116
DOI:10.1080/13880209.2019.1569697