دورية أكاديمية
Clinical manifestations and indicators of the hemostasis system in patients with nonalcoholic fatty liver disease with an immune response to SARS-CoV-2
| العنوان: | Clinical manifestations and indicators of the hemostasis system in patients with nonalcoholic fatty liver disease with an immune response to SARS-CoV-2 |
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| المؤلفون: | V.I. Didenko, V.B. Yagmur, I.A. Klenina, O.M. Tatarchuk, K.A. Ruban, O.P. Petishko |
| المصدر: | Gastroenterologìa, Vol 57, Iss 3, Pp 159-165 (2023) |
| بيانات النشر: | Zaslavsky O.Yu., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | nonalcoholic fatty liver disease, sars-cov-2, platelet link of the hemostasis system, coagulation factor ii, plasminogen activator inhibitor-1, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Background. Nonalcoholic fatty liver disease (NAFLD) is often accompanied by comorbid conditions such as obesity, type 2 diabetes, and cardiovascular diseases, which are risk factors for severe coronavirus disease (COVID-19). The latter is characterized by respiratory failure and hyperinflammation with the risk of further multiorgan failure, and disorders in the hemostasis system. Purpose: to determine the clinical manifestations and features of hemostasis in NAFLD in patients with an immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Materials and methods. Thirty-seven patients with NAFLD were under observation, and immunoglobulins G to SARS-CoV-2 were detected in them. Group I consisted of 19 patients who did not suffer from COVID-19. Group II included 18 patients with COVID-19 confirmed by a polymerase chain reaction. Patients of groups I and II were vaccinated against coronavirus. Clinical symptoms, the state of hemostasis in the vascular-platelet link, the state of coagulation, the content of fibrinogen and plasminogen activator inhibitor-1 (PAI-1) were assessed in all patients. Results. Patients with NAFLD and an immune response to SARS-CoV-2 reported a pain syndrome in 70.3 % of cases: group I more often complained of pain in the right (68.4 %) and left (52.6 %) hypochondria, group II — of epigastric pain (66.7 %). Among manifestations of dyspeptic syndrome observed in 28 (75.7 %) patients, in group I complaints of abdominal distension (31.6 %) and stomach rumble (21.1 %) prevailed, in group II — of abdominal distension (50.0 %) and bitter taste in mouth (27.8 %). Concomitant cardiovascular pathology was detected in 32.4 % of cases. The synthetic function of the liver in terms of coagulation factors was almost preserved, but a probable increase in the content of coagulation factor II was observed in patients of group I (p 0.05). Meanwhile, among patients with COVID-19, abdominal bloating (by 1.6 times) and bitter taste in mouth (by 2 times) prevailed, and in the hemostasis system, a decrease in the number of platelets was noted compared to the controls (p > 0.05). Patients of both groups had an increase in the average number of platelets by 10 % (p > 0.05). A significant increase by 20 % (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Ukrainian |
| تدمد: | 2308-2097 2518-7880 |
| Relation: | https://gastro.zaslavsky.com.ua/index.php/journal/article/view/555; https://doaj.org/toc/2308-2097; https://doaj.org/toc/2518-7880 |
| DOI: | 10.22141/2308-2097.57.3.2023.555 |
| URL الوصول: | https://doaj.org/article/31107e7cc3a6404badee8b21fd9c19cc |
| رقم الأكسشن: | edsdoj.31107e7cc3a6404badee8b21fd9c19cc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23082097 25187880 |
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| DOI: | 10.22141/2308-2097.57.3.2023.555 |