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TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses

التفاصيل البيبلوغرافية
العنوان: TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses
المؤلفون: Nicoletta Caronni, Giulia Maria Piperno, Francesca Simoncello, Oriana Romano, Simone Vodret, Yuichi Yanagihashi, Regine Dress, Charles-Antoine Dutertre, Mattia Bugatti, Pierre Bourdeley, Annalisa Del Prete, Tiziana Schioppa, Emilia Maria Cristina Mazza, Licio Collavin, Serena Zacchigna, Renato Ostuni, Pierre Guermonprez, William Vermi, Florent Ginhoux, Silvio Bicciato, Shigekatzu Nagata, Federica Benvenuti
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
بيانات النشر: Nature Portfolio, 2021.
سنة النشر: 2021
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated cDC1 is associated with less efficient uptake of cell associated antigens and reduction of CD8 + T cell activation in advanced lung tumors.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-021-22535-z
URL الوصول: https://doaj.org/article/ed313efe49174e4e8c4bd8e169965081
رقم الأكسشن: edsdoj.313efe49174e4e8c4bd8e169965081
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20411723
DOI:10.1038/s41467-021-22535-z