دورية أكاديمية
Accuracy of angiopoietin-2 for predicting organ failure in patients with acute pancreatitis: a systematic review and meta-analysis
العنوان: | Accuracy of angiopoietin-2 for predicting organ failure in patients with acute pancreatitis: a systematic review and meta-analysis |
---|---|
المؤلفون: | Yongcai Lv, Yanhua Yao, Qi Liu, Jingjing Lei |
المصدر: | Journal of International Medical Research, Vol 49 (2021) |
بيانات النشر: | SAGE Publishing, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Medicine (General) |
مصطلحات موضوعية: | Medicine (General), R5-920 |
الوصف: | Objective Our aim was to assess the accuracy of angiopoietin-2 (Ang-2) as a prognostic marker for acute pancreatitis (AP) with organ failure (OF). Methods We undertook a systematic search of the PubMed, Cochrane Library, Embase, Chinese Journals Full-text, Wanfang, China Biology Medicine disc, and Weipu databases to identify eligible cohort studies on the predictive value of Ang-2 for AP with OF. The main outcome measures were sensitivity and specificity. The effects were pooled using a bivariate mixed-effects model. Results Six articles with seven case-control studies (n = 650) were included. Pooled sensitivity, specificity, and positive and negative likelihood ratios with 95% confidence intervals (CI) for AP with OF were 0.93 (95%CI: 0.75–0.99), 0.85 (95%CI: 0.75–0.92), 6.40 (95%CI: 3.36–12.19), and 0.08 (95%CI: 0.02–0.36), respectively. The area under the summary receiver operating characteristic curve was 0.95 (95%CI: 0.92–0.96), and the diagnostic odds ratio was 83.18 (95%CI: 11.50–623.17). Subgroup analysis showed that admission time of AP onset (< or ≥24 hours) was a source of overall heterogeneity. Sensitivity analysis supported this finding. Conclusion Ang-2 had high diagnostic accuracy for AP with OF; the best prediction of Ang-2 may be 24 to 72 hours after onset of AP. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1473-2300 03000605 |
Relation: | https://doaj.org/toc/1473-2300 |
DOI: | 10.1177/0300060520986708 |
URL الوصول: | https://doaj.org/article/a315f1876cf94f0ba364a46c23966ebc |
رقم الأكسشن: | edsdoj.315f1876cf94f0ba364a46c23966ebc |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14732300 03000605 |
---|---|
DOI: | 10.1177/0300060520986708 |