دورية أكاديمية
Chronic stress promotes basal ganglia disinhibition by increasing the excitatory drive of direct-pathway neurons
| العنوان: | Chronic stress promotes basal ganglia disinhibition by increasing the excitatory drive of direct-pathway neurons |
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| المؤلفون: | Diana Rodrigues, Patricia Monteiro |
| المصدر: | Neurobiology of Stress, Vol 27, Iss , Pp 100571- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system LCC:Neurophysiology and neuropsychology |
| مصطلحات موضوعية: | Chronic stress, Dorsomedial striatum, Medial prefrontal cortex, Direct-pathway neurons, Hyperactivation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429, Neurophysiology and neuropsychology, QP351-495 |
| الوصف: | Chronic stress (CS) is a well-recognized triggering factor in obsessive-compulsive disorder (OCD) and Tourette's syndrome (TS), two neuropsychiatric disorders characterized by the presence of stereotypic motor symptoms. Planning and execution of motor actions are controlled by the dorsal striatum, a brain region that promotes or suppresses motor movement by activating striatal neurons from the direct- or indirect-pathway, respectively. Despite the dorsal striatum being affected in motor disorders and by CS exposure, how CS affects the two opposing pathways is not fully understood. Here, we report that CS in mice selectively potentiates the direct-pathway, while sparing the indirect-pathway. Specifically, we show that CS both increases excitation and reduces inhibition over direct-pathway neurons in the dorsomedial striatum (DMS). Furthermore, inhibitory interneurons located in the DMS also display reduced excitatory drive after chronic stress, thus amplifying striatal disinhibition. Altogether, we propose a model where both increased excitatory drive and decreased inhibitory drive in the striatum causes disinhibition of basal ganglia's motor direct pathway - a mechanism that might explain the emergence of motor stereotypies and tic disorders under stress. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-2895 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352289523000590; https://doaj.org/toc/2352-2895 |
| DOI: | 10.1016/j.ynstr.2023.100571 |
| URL الوصول: | https://doaj.org/article/316199cd739a4d15beaef50ed68e52f7 |
| رقم الأكسشن: | edsdoj.316199cd739a4d15beaef50ed68e52f7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23522895 |
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| DOI: | 10.1016/j.ynstr.2023.100571 |