دورية أكاديمية
Ablative Fractional Laser-assisted Low-irradiance Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients: A Prospective, Randomized, Intraindividual Controlled Trial
| العنوان: | Ablative Fractional Laser-assisted Low-irradiance Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients: A Prospective, Randomized, Intraindividual Controlled Trial |
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| المؤلفون: | Anke S. Lonsdorf, Aric Keller, Julia Hartmann, Alexander H. Enk, Patrick Gholam |
| المصدر: | Acta Dermato-Venereologica, Vol 102 (2022) |
| بيانات النشر: | Medical Journals Sweden, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Dermatology |
| مصطلحات موضوعية: | actinic keratosis, keratinocyte cancer, organ transplant recipients, photodynamic therapy, immunosuppression, Dermatology, RL1-803 |
| الوصف: | Pain and inferior efficacy are major limiting factors of conventional photodynamic therapy for the field treatment of actinic keratoses in immunosuppressed organ transplant recipients. This prospective randomized controlled study evaluates the efficacy and tolerability of ablative fractional laser system pretreatment combined with low-irradiance photodynamic therapy (18.5 mW/cm2) compared with conventional photodynamic therapy (61.67 mW/cm2) in the treatment of actinic keratoses on the face and scalp in organ transplant recipients, using a red light-emitting diode lamp at a total light dose of 37 J/cm2. Low-irradiance photodynamic therapy combined with Er:YAG pretreatment achieved a significantly superior lesion response rate (mean ± standard deviation 77.3 ± 23.6%) compared with conventional photodynamic therapy (61.8 ± 21.4%; p = 0.025) in intra-individual fields at 3 months without negatively impacting pain (p = 0.777) or cosmetic outcome (p = 0.157). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0001-5555 1651-2057 |
| Relation: | https://medicaljournalssweden.se/actadv/article/view/1057; https://doaj.org/toc/0001-5555; https://doaj.org/toc/1651-2057 |
| DOI: | 10.2340/actadv.v102.1057 |
| URL الوصول: | https://doaj.org/article/316990e932ba4f36829c513cf49f39ab |
| رقم الأكسشن: | edsdoj.316990e932ba4f36829c513cf49f39ab |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00015555 16512057 |
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| DOI: | 10.2340/actadv.v102.1057 |