دورية أكاديمية
أعرض في EDS

Iron deposition following chronic myocardial infarction as a substrate for cardiac electrical anomalies: initial findings in a canine model.

التفاصيل البيبلوغرافية
العنوان: Iron deposition following chronic myocardial infarction as a substrate for cardiac electrical anomalies: initial findings in a canine model.
المؤلفون: Ivan Cokic, Avinash Kali, Xunzhang Wang, Hsin-Jung Yang, Richard L Q Tang, Anees Thajudeen, Michael Shehata, Allen M Amorn, Enzhao Liu, Brian Stewart, Nathan Bennett, Doron Harlev, Sotirios A Tsaftaris, Warren M Jackman, Sumeet S Chugh, Rohan Dharmakumar
المصدر: PLoS ONE, Vol 8, Iss 9, p e73193 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Iron deposition has been shown to occur following myocardial infarction (MI). We investigated whether such focal iron deposition within chronic MI lead to electrical anomalies.Two groups of dogs (ex-vivo (n = 12) and in-vivo (n = 10)) were studied at 16 weeks post MI. Hearts of animals from ex-vivo group were explanted and sectioned into infarcted and non-infarcted segments. Impedance spectroscopy was used to derive electrical permittivity ([Formula: see text]) and conductivity ([Formula: see text]). Mass spectrometry was used to classify and characterize tissue sections with (IRON+) and without (IRON-) iron. Animals from in-vivo group underwent cardiac magnetic resonance imaging (CMR) for estimation of scar volume (late-gadolinium enhancement, LGE) and iron deposition (T2*) relative to left-ventricular volume. 24-hour electrocardiogram recordings were obtained and used to examine Heart Rate (HR), QT interval (QT), QT corrected for HR (QTc) and QTc dispersion (QTcd). In a fraction of these animals (n = 5), ultra-high resolution electroanatomical mapping (EAM) was performed, co-registered with LGE and T2* CMR and were used to characterize the spatial locations of isolated late potentials (ILPs).Compared to IRON- sections, IRON+ sections had higher[Formula: see text], but no difference in[Formula: see text]. A linear relationship was found between iron content and [Formula: see text] (p1.5%)) with similar scar volumes (7.28% ± 1.02% (Iron (1.5%)), p = 0.51) but markedly different iron volumes (1.12% ± 0.64% (Iron (1.5%)), p = 0.02), QT and QTc were elevated and QTcd was decreased in the group with the higher iron volume during the day, night and 24-hour period (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3774668?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0073193
URL الوصول: https://doaj.org/article/3196c0363e9b403b88be36722815c6fc
رقم الأكسشن: edsdoj.3196c0363e9b403b88be36722815c6fc
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0073193