دورية أكاديمية
Development of Folate-Functionalized PEGylated Zein Nanoparticles for Ligand-Directed Delivery of Paclitaxel
| العنوان: | Development of Folate-Functionalized PEGylated Zein Nanoparticles for Ligand-Directed Delivery of Paclitaxel |
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| المؤلفون: | Zar Chi Soe, Wenquan Ou, Milan Gautam, Kishwor Poudel, Bo Kyun Kim, Le Minh Pham, Cao Dai Phung, Jee-Heon Jeong, Sung Giu Jin, Han-Gon Choi, Sae Kwang Ku, Chul Soon Yong, Jong Oh Kim |
| المصدر: | Pharmaceutics, Vol 11, Iss 11, p 562 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | folic acid, paclitaxel, nanoparticle, zein, Pharmacy and materia medica, RS1-441 |
| الوصف: | In this study, we investigated the active targeted delivery of a hydrophobic drug, paclitaxel (PTX), via receptor-mediated endocytosis by folate receptors expressed on cancer cells using a protein-based nanoparticle system. PTX was loaded on zein nanoparticles and conjugated with folate (PTX/Zein-FA) to estimate its chemotherapeutic efficacy in folate receptor-expressing KB cancer cells. PTX/Zein-FA nanoparticles were successfully developed, with a nanoparticle size of ~180 nm and narrow polydispersity index (~0.22). Accelerated release of PTX in an acidic environment was observed for PTX/Zein-FA. An in vitro cellular study of PTX/Zein-FAs in KB cells suggested that PTX/Zein-FA improved the cytotoxic activity of PTX on folate receptors overexpressed in cancer cells by inducing proapoptotic proteins and inhibiting anti-apoptotic proteins. In addition, PTX/Zein-FA exhibited anti-migratory properties and could alter the cell cycle profile of KB cells. A549 cells, which are folate receptor-negative cancer cells, showed no significant enhancement in the in vitro cellular activities of PTX/Zein-FA. We describe the antitumor efficacy of PTX/Zein-FA in KB tumor-bearing mice with minimum toxicity in healthy organs, and the results were confirmed in comparison with free drug and non-targeted nanoparticles. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1999-4923 11110562 |
| Relation: | https://www.mdpi.com/1999-4923/11/11/562; https://doaj.org/toc/1999-4923 |
| DOI: | 10.3390/pharmaceutics11110562 |
| URL الوصول: | https://doaj.org/article/31fcd111e6de4ac69ef9df2a2d212a16 |
| رقم الأكسشن: | edsdoj.31fcd111e6de4ac69ef9df2a2d212a16 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19994923 11110562 |
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| DOI: | 10.3390/pharmaceutics11110562 |