دورية أكاديمية
A natural heparinoid from mollusc Meretrix lusoria: Purification, structural characterization, and antithrombotic evaluation
| العنوان: | A natural heparinoid from mollusc Meretrix lusoria: Purification, structural characterization, and antithrombotic evaluation |
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| المؤلفون: | Jing Chen, Zhenxing Du, Bingbing Song, Rui Li, Xuejing Jia, Jianping Chen, Xiaofei Liu, Saiyi Zhong |
| المصدر: | Current Research in Food Science, Vol 5, Iss , Pp 1897-1905 (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Food processing and manufacture |
| مصطلحات موضوعية: | Heparinoid, Shellfish, Antithrombotic activity, Hemorrhagic effect, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456 |
| الوصف: | Heparinoid, a sulfate polysaccharide derived from marine organisms was attracted largely attention due to its versatile activities. A naturally occurring heparinoid (M2) that was extracted from the mollusk Meretrix lusoria and used in this investigation shown strong antithrombotic action. UV–Vis, FT-IR, SAX-HPLC, and NMR were used to explore the structural characteristics of M2, results indicated that M2 similar with heparin, its average molecular weight was 22.58 kDa. Which was primarily made up of→4)-α-IdoA2S-(1→4)-α-GlcNS6S-(1→ (31.19%), →4)-β-GlcA-(1→4)-α-GlcNAc (1→ (23.21%), →4)-β-GlcA-(1→4)-α-GlcNS (1→ (13.87%), →4)-α-IdoA2S-(1→4)-α-GlcNS (1→ (8.95%), →4)-β-GlcA-(1→4)-α-GlcNAc6S (1→ (7.39%) and →4)-β-GlcA-(1→4)-α-GlcNS6S (1→ (7.63%). The antithrombotic activity of M2 was evaluated using measurements of the anticoagulant effect in vitro and the fibrinolytic capability in vitro and in vivo, and M2 has 122.4 U/mg of anticoagulant activity and 1.41 U/mg of fibrinolytic activity, respectively. Additionally, a mouse tail-cutting model was used to assess the bleeding effect in real time, it found that M2 had a reduced hemorrhagic risk than heparin. Consequently, M2 could be exploited to develop functional foods or medications with antithrombotic properties. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2665-9271 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2665927122001800; https://doaj.org/toc/2665-9271 |
| DOI: | 10.1016/j.crfs.2022.10.010 |
| URL الوصول: | https://doaj.org/article/ed329663b4754a97b4f85e0f77a57c66 |
| رقم الأكسشن: | edsdoj.329663b4754a97b4f85e0f77a57c66 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 26659271 |
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| DOI: | 10.1016/j.crfs.2022.10.010 |