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Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey.

التفاصيل البيبلوغرافية
العنوان: Changes in vitamin D status considering hemodilution factors in Japanese pregnant women according to trimester: A longitudinal survey.
المؤلفون: Nobuko Takaoka, Keiko Nishida, Toshimi Sairenchi, Mitsumasa Umesawa, Rie Noguchi, Katsumi Someya, Gen Kobashi
المصدر: PLoS ONE, Vol 15, Iss 10, p e0239954 (2020)
بيانات النشر: Public Library of Science (PLoS), 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: ObjectivesThere have been no longitudinal surveys on the changes in 25-hydroxyvitamin D [25(OH)D] while considering hemodilution factors among pregnant Japanese women. Therefore, we examined 25(OH)D levels as well as red blood cell count (RBC), hemoglobin (Hb), and Hematocrit (Hct) at the three trimesters among pregnant Japanese women to determine the distribution of serum 25(OH)D levels and the influence of hemodilution.DesignThis was a longitudinal study.SettingThe study was conducted at Ibaraki Seinan Medical Center Hospital in Japan.ParticipantsThe participants comprised 50 women in the first trimester with singleton pregnancies and without any complications.Outcome measuresParticipants were recruited from June to August 2018, and followed up till their postpartum period. Blood samples were collected at the first, second, and third trimesters, i.e., at 4-15, 16-27, and 28-39 weeks, respectively. 25(OH)D levels, RBC, Hb, and Hct were analyzed across the three trimesters.ResultsComparing the first, second, and third trimesters, 25(OH)D, RBC, and Hb were significantly declined in the second and third trimesters (p < 0.001). According to Spearman's correlation coefficient with 25(OH)D and RCB, Hb, Hct, significant correlations were found between 25(OH)D and Hb (p < 0.001), as well as Hct (p < 0.001) in the third trimester.ConclusionsThe present study had two major findings. First, it showed that the vitamin D status of most pregnant Japanese women were considered as vitamin D deficient. Second, the maternal serum 25(OH)D levels, RBC, Hb, and Hct of the pregnant women declined in the second and third trimesters. Thus we propose to have routine screening of vitamin D status of pregnant women, especially in the second trimester.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0239954
URL الوصول: https://doaj.org/article/d32995e6ec034e8dabacd56598461b55
رقم الأكسشن: edsdoj.32995e6ec034e8dabacd56598461b55
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0239954