دورية أكاديمية
Effect of Ambrosia arborescens Mill. ethanolic extract on breast cancer induced in rats
| العنوان: | Effect of Ambrosia arborescens Mill. ethanolic extract on breast cancer induced in rats |
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| المؤلفون: | Carmen R. Silva-Correa, Victor E. Villarreal-La Torre, Gladys E. Lozano-Ciudad, Ricardo M. Gomez-Arce, Julio A. Castaneda-Carranza, Deivy Y. Dionicio-Rosado, Maria E. Cotrina-Leon, William A. Sagastegui-Guarniz, Cesar D. Gamarra-Sanchez, Jose L. Cruzado-Razco |
| المصدر: | Veterinary World, Vol 17, Iss 3, Pp 700-704 (2024) |
| بيانات النشر: | Veterinary World, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Animal culture LCC:Veterinary medicine |
| مصطلحات موضوعية: | 12-dimethylbenz[a]anthracene, ambrosia arborescens, breast carcinoma in situ, cancer, rat, Animal culture, SF1-1100, Veterinary medicine, SF600-1100 |
| الوصف: | Background and Aim: Ambrosia arborescens Mill. (A. arborescens) is an aromatic plant used in traditional medicine as an anti-inflammatory, anti-tussive, anti-rheumatic, and anti-diarrheal agent. This study aimed to evaluate the effect of A. arborescens Mill. on a Rattus norvegicus var. albinus-induced breast cancer model. Materials and Methods: We collected A. arborescens from the province of Julcan, La Libertad Region, Per, and prepared an ethanolic extract using pulverized leaves macerated in 96° ethanol for 72 h with magnetic stirring. In the evaluation of anticancer activity, four experimental groups with 10 female rats each were formed: Group I (Control-7,12-dimethylbenz[a] anthracene [DMBA]), which received DMBA (single dose) and physiological saline solution for 4 months, and Groups II, III, and IV, which received DMBA (single dose) and 200, 400, and 600 mg/kg/day of the ethanolic extract of A. arborescens, respectively, for 4 months. Results: The DMBA control group presented histological characteristics of ductal carcinoma in situ with necrotic and inflammatory areas, whereas the A. arborescens extract group showed a decrease in tumor volume and recovery of the ductal duct. Conclusion: Ethanol extract of A. arborescens leaves decreases tumor development in rats with induced breast cancer, and this effect is dose-dependent. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0972-8988 2231-0916 |
| Relation: | https://www.veterinaryworld.org/Vol.17/March-2024/22.pdf; https://doaj.org/toc/0972-8988; https://doaj.org/toc/2231-0916 |
| DOI: | 10.14202/vetworld.2024.700-704 |
| URL الوصول: | https://doaj.org/article/32b3783201924143a1fd7225b76d24ae |
| رقم الأكسشن: | edsdoj.32b3783201924143a1fd7225b76d24ae |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09728988 22310916 |
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| DOI: | 10.14202/vetworld.2024.700-704 |