دورية أكاديمية
Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis
| العنوان: | Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis |
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| المؤلفون: | Kyana Jafarabady, Arman Shafiee, Razman Arabzadeh Bahri, Ida Mohammadi, Mohammad javad Amini, Shahryar Rajai, Diba Akbarzadeh, Faeze Soltani Abhari, Emad Movahed, Soraya Parvari, Mahmood Bakhtiyari |
| المصدر: | BMC Women's Health, Vol 24, Iss 1, Pp 1-9 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Gynecology and obstetrics LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Endometriosis, Brain-derived neurotrophic factor, BDNF, Gynecology and obstetrics, RG1-991, Public aspects of medicine, RA1-1270 |
| الوصف: | Abstract Background The existing literature on the association between BDNF protein levels and endometriosis presents inconsistent findings. This systematic review and meta-analysis aim to synthesize the available evidence and evaluate the possible relationship between BDNF protein levels and endometriosis. Methods Electronic databases (PubMed, Embase, Scopus, PsycINFO, and Web of Science) were used to conduct a comprehensive literature search from inception to June 2023. The search strategy included relevant keywords and medical subject headings (MeSH) terms related to BDNF, endometriosis, and protein levels. A random-effects model was used for the meta-analysis, and to explore heterogeneity subgroup analyses were performed. funnel plots and statistical tests were used for assessing the publication bias. Results A total of 12 studies were included. The pooled standardized mean difference (SMD) of BDNF levels between women with endometriosis and controls was 0.87 (95% confidence interval [CI] 0.34 to 1.39, p = 0.001; I2 = 93%). The results showed that blood levels of BDNF are significantly higher in endometriosis patients (SMD: 1.13 95% CI 0.54 to 1.73, p = 0.0002; I2 = 93%). No significant publication bias was observed based on the results of Egger’s regression test ((p = 0.15). Conclusion This study revealed a significant difference between patients diagnosed with endometriosis and healthy control in the level of BDNF. The results indicate that women with endometriosis have higher levels of BDNF. Further studies are needed to be undertaken to investigate the role of BDNF in endometriosis pathophysiology and the diagnostic value of BDNF in endometriosis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1472-6874 |
| Relation: | https://doaj.org/toc/1472-6874 |
| DOI: | 10.1186/s12905-023-02877-0 |
| URL الوصول: | https://doaj.org/article/32c50b92727f47dcab6275c4938ef601 |
| رقم الأكسشن: | edsdoj.32c50b92727f47dcab6275c4938ef601 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14726874 |
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| DOI: | 10.1186/s12905-023-02877-0 |