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Role of cardiopulmonary exercise test in the prediction of hemodynamic impairment in patients with pulmonary arterial hypertension

التفاصيل البيبلوغرافية
العنوان: Role of cardiopulmonary exercise test in the prediction of hemodynamic impairment in patients with pulmonary arterial hypertension
المؤلفون: B. Pezzuto, R. Badagliacca, M. Muratori, S. Farina, M. Bussotti, M. Correale, A. Bonomi, C. Vignati, S. Sciomer, S. Papa, E. Palazzo Adriano, P. Agostoni
المصدر: Pulmonary Circulation, Vol 12, Iss 1, Pp n/a-n/a (2022)
بيانات النشر: Wiley, 2022.
سنة النشر: 2022
المجموعة: LCC:Diseases of the circulatory (Cardiovascular) system
LCC:Diseases of the respiratory system
مصطلحات موضوعية: cardiopulmonary exercise test, oxygen uptake, pulmonary arterial hypertension, right heart catheterization, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the respiratory system, RC705-779
الوصف: Abstract Periodic repetition of right heart catheterization (RHC) in pulmonary arterial hypertension (PAH) can be challenging. We evaluated the correlation between RHC and cardiopulmonary exercise test (CPET) aiming at CPET use as a potential noninvasive tool for hemodynamic burden evaluation. One hundred and forty‐four retrospective PAH patients who had performed CPET and RHC within 2 months were enrolled. The following analyses were performed: (a) CPET parameters in hemodynamic variables tertiles; (b) position of hemodynamic parameters in the peak end‐tidal carbon dioxide pressure (PETCO2) versus ventilation/carbon dioxide output (VE/VCO2) slope scatterplot, which is a specific hallmark of exercise respiratory abnormalities in PAH; (c) association between CPET and a hemodynamic burden score developed including mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance (PVR), cardiac index, and right atrial pressure. VE/VCO2 slope and peak PETCO2 significantly varied in mPAP and PVR tertiles, while peak oxygen uptake (peak VO2) and O2 pulse varied in the tertiles of all hemodynamic parameters. PETCO2 versus VE/VCO2 slope showed a strong hyperbolic relationship (R2 = 0.7627). Patients with peak PETCO2 > median (26 mmHg) and VE/VCO2 slope < median (44) presented lower mPAP and PVR (p median. Multivariate analysis individuated peak VO2 (p = 0.0158) and peak PETCO2 (p = 0.0089) as hemodynamic score independent predictors; the formula 11.584 − 0.0925 × peak VO2 − 0.0811 × peak PETCO2 best predicts the hemodynamic score value from CPET data. A significant correlation was found between estimated and calculated scores (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-8940
Relation: https://doaj.org/toc/2045-8940
DOI: 10.1002/pul2.12044
URL الوصول: https://doaj.org/article/33ad4947f1f64257a291074ce4f0c6ed
رقم الأكسشن: edsdoj.33ad4947f1f64257a291074ce4f0c6ed
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20458940
DOI:10.1002/pul2.12044