دورية أكاديمية
أعرض في EDS

Preoperative hematological inflammatory markers associated with grade and survival in Meningiomas

التفاصيل البيبلوغرافية
العنوان: Preoperative hematological inflammatory markers associated with grade and survival in Meningiomas
المؤلفون: Camila Batista de Oliveira Silva, Bruna Araújo, Bárbara Roberta Ongaratti, Tainá Mafalda dos Santos, Carolina Garcia Soares Leães Rech, Lígia Barbosa Coutinho, Nelson Pires Ferreira, Miriam da Costa Oliveira, Julia Fernanda Semmelmann Pereira-Lima
المصدر: Surgical and Experimental Pathology, Vol 5, Iss 1, Pp 1-8 (2022)
بيانات النشر: BMC, 2022.
سنة النشر: 2022
المجموعة: LCC:Surgery
LCC:Pathology
مصطلحات موضوعية: Meningiomas, Grade, Recurrence, Neutrophils, anemia, Survival, Surgery, RD1-811, Pathology, RB1-214
الوصف: Abstract Meningiomas represent the most frequently diagnosed intracranial tumors. Inflammatory cells present in the tumor can modulate both antitumor and protumor functions, and modify the therapeutic response. Hematological inflammatory parameters have provided prognostic information useful in the treatment and clinical evaluation of several tumors. The aim of this study was to evaluate preoperative hematological markers of patients with meningiomas and to relate them to clinical variables and recurrence-regrowth free survival. Eighty-nine patients without corticosteroid therapy were included. Blood test results and tumor characteristics were collected from medical records. Associations between clinical characteristics and the recurrence-regrowth free survival (RFS) were evaluated using Cox proportional hazard analysis and Kaplan-Meier curves. The receiver operating characteristic (ROC) curves were constructed. Of the 89 cases, 73 (82%) were grade I and 16 (18%) grade II. The mean age was 53 ± 13.9 years, with higher frequency in women. Anemia was observed in 23.6% and neutrophilia in 42% of the patients. In univariate analysis, anemia (p = 0.04), neutrophilia (p = 0.02) and neutrophil/lymphocyt ratio (NLR) (p = 0.02) were associated with an increased risk of recurrence-regrowth and shorter RFS. In multivariate analysis, anemia and NLR > 4.1 represented a higher risk of recurrence-regrowth (p = 0.003). The ROC curve analysis showed that only the lymphocyte/monocyte (L/M) > 2.5 was able to predict the tumor grade. The preoperative presence of anemia, neutrophilia, NLR > 4.1 and L/M > 2.5 were associated with a worse prognosis in meningiomas. The use of preoperative hematological inflammatory parameters as prognostic factors can be promissing for evaluation and follow-up of meningiomas.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2520-8454
Relation: https://doaj.org/toc/2520-8454
DOI: 10.1186/s42047-022-00106-w
URL الوصول: https://doaj.org/article/a342aecdc76944e88bf724497dbf8e51
رقم الأكسشن: edsdoj.342aecdc76944e88bf724497dbf8e51
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:25208454
DOI:10.1186/s42047-022-00106-w